Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NDUFS8 | O00217 | 1/20 | 0.37 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873684 | 0.83 | USP9X (0.49) | KMT2ALMNAMEN1ALDH1A1MAPK1 | |
| SCHEMBL864620 | 0.77 | USP9X (0.44) | ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL1934969 | 0.72 | MMP1 (0.60) | KMT2ALMNAMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL874041 | 0.72 | MAPK1 (0.39) | KMT2ALMNAMEN1ALDH1A1MAPK1 | |
| SCHEMBL874538 | 0.70 | MEN1 (0.47) | KMT2ALMNAMEN1ALDH1A1MAPK1 | |
| SCHEMBL873551 | 0.69 | RECQL (0.41) | KMT2ALMNAMEN1ALDH1A1MAPK1 | |
| SCHEMBL873696 | 0.68 | USP9X (0.52) | KMT2ALMNAMEN1ALDH1A1MAPK1 | |
| SCHEMBL10125036 | 0.68 | USP9X (0.40) | ALDH1A1HTT | |
| SCHEMBL874558 | 0.67 | USP9X (0.51) | KMT2ALMNAMEN1ALDH1A1MAPK1 | |
| SCHEMBL20171512 | 0.66 | USP9X (0.44) | LMNAALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619184-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of the University of Michigan (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040527-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | WO | disclosed |