Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.65 |
| ▸ | DHODH | Q02127 | 14/20 | 0.57 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28536199 | 0.97 | PDE10A (0.69) | PDE10ADHODHPDK1KDM4EALDH1A1 | |
| SCHEMBL8735048 | 0.87 | DHODH (0.62) | PDE10ADHODHPDK1ALDH1A1 | |
| SCHEMBL8733061 | 0.86 | DHODH (0.53) | PDE10ADHODHPDK1MAPK14MBNL1 | |
| SCHEMBL8732571 | 0.85 | DHODH (0.62) | PDE10ADHODHMBNL1DHFRALKBH5 | |
| SCHEMBL29942008 | 0.85 | DHODH (0.62) | PDE10ADHODHMBNL1DHFRALKBH5 | |
| SCHEMBL28085639 | 0.83 | PDE10A (0.74) | PDE10APDK1MAPK14MBNL1TDP1 | |
| SCHEMBL14341086 | 0.83 | PDE10A (0.93) | PDE10ADHODHPDK1KDM4EALDH1A1 | |
| SCHEMBL12970097 | 0.80 | PDK1 (0.47) | PDE10ADHODHPDK1KDM4EMAPK14 | |
| SCHEMBL12970115 | 0.80 | PDK1 (0.45) | PDE10ADHODHPDK1KDM4EMAPK14 | |
| SCHEMBL28529940 | 0.80 | PDE10A (0.73) | PDE10ADHODHKDM4EALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537191-B1 | TREATMENT OF ORGAN TRANSPLANTATION REJECTION | DU PONT MERCK PHARMA (US) | 1998-04-29 | — | — | EP | claimed |
| EP-0339485-B1 | 4-QUINOLINE CARBOXYLIC ACID DERIVATIVES USEFUL AS IMMUNOSUPPRESSIVE AGENTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-03-31 | — | — | EP | claimed |