Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875479 | 0.89 | NAMPT (0.40) | NAMPTCHRNA7MAPTTRPV1L3MBTL1 | |
| SCHEMBL873658 | 0.84 | NAMPT (0.39) | NAMPTCHRNA7MAPTTRPV1L3MBTL1 | |
| SCHEMBL874058 | 0.84 | NAMPT (0.42) | NAMPTCHRNA7MKNK2DRD2DRD3 | |
| SCHEMBL874516 | 0.84 | NAMPT (0.39) | NAMPTCHRNA7MAPTTRPV1L3MBTL1 | |
| SCHEMBL873821 | 0.83 | NAMPT (0.39) | NAMPTCHRNA7MAPTTRPV1AKT1 | |
| SCHEMBL875501 | 0.82 | CHRNA7 (0.40) | NAMPTCHRNA7MAPTTRPV1KDM4E | |
| SCHEMBL874536 | 0.82 | NAMPT (0.45) | NAMPTCHRNA7MAPTRAB9AALDH1A1 | |
| SCHEMBL874339 | 0.82 | MKNK1 (0.39) | NAMPTCHRNA7MKNK1MKNK2MAPT | |
| SCHEMBL874016 | 0.81 | NAMPT (0.37) | NAMPTCHRNA7MAPTDRD2DRD3 | |
| SCHEMBL877181 | 0.80 | NAMPT (0.40) | NAMPTCHRNA7MAPTTRPV1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |