SCHEMBL8736663

SCHEMBL8736663

O=C(O)c1ccc(Oc2ccc(C(=O)O)cc2-c2ccc(O)cc2)c(-c2ccc(O)cc2)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.50
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
CA4 P22748 2/20 0.50
CA6 P23280 2/20 0.50
CA7 P43166 2/20 0.50
CA9 Q16790 2/20 0.50
CA14 Q9ULX7 2/20 0.50
CA3 P07451 1/20 0.50
TYR P14679 1/20 0.50
DRD1 P21728 1/20 0.50
CA5A P35218 1/20 0.50
CA5B Q9Y2D0 1/20 0.50
MMP2 P08253 1/20 0.49
MMP3 P08254 1/20 0.49
HSD17B10 Q99714 1/20 0.47
TTR P02766 2/20 0.46
SRD5A2 P31213 1/20 0.46
TPMT P51580 1/20 0.44
CSNK2A2 P19784 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6248649 0.87 LMNA (0.59) CA12CA1CA2CA4CA6
SCHEMBL10959508 0.85 RAB9A (0.46) CA12CA1CA2CA4CA6
SCHEMBL6058606 0.82 HSD17B10 (0.58) CA12CA1CA2CA4CA6
SCHEMBL9716700 0.79 ESR1 (0.49) CA12CA1CA2CA4CA6
SCHEMBL9389773 0.79 HSD17B10 (0.59) CA12CA1CA2CA4CA6
SCHEMBL28211489 0.78 HSD17B10 (0.58) CA12CA1CA2CA4CA6
SCHEMBL3220340 0.77 TSHR (0.55) CA12CA1CA2CA4CA6
SCHEMBL3199834 0.76 TSHR (0.53) CA12CA1CA2CA4CA6
SCHEMBL2788717 0.75 HSD17B10 (0.76) CA12CA1CA2CA4CA6
SCHEMBL8082912 0.74 SRD5A2 (0.61) CA12CA1CA2CA4CA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0488263-B1 Polyester resin compositions MITSUBISHI RAYON CO (JP) 1998-02-25 EP disclosed
EP-0476293-B1 Polyester resin compositions MITSUBISHI RAYON CO (JP) 1996-11-20 EP disclosed
EP-0430134-B1 High impact graft copolymers and resin compositions MITSUBISHI RAYON CO (JP) 1996-07-31 EP disclosed
US-5334656-A Molding material blend of polyester and acrylate/polysiloxane graft polymer containing an epoxy group; impact strength; cold resistance; good appearance MATSUBISHI RAYON CO., LTD. (JP) 1994-08-02 US disclosed
EP-0313852-B1 Aromatic polyester-polyorganosiloxane block copolymer MITSUBISHI RAYON CO (JP) 1994-01-12 EP disclosed
US-5191036-A Polycarbonate, aromatic polyestersiloxane block polymer, impact strength MITSUBISHI RAYON CO., LTD. (JP) 1993-03-02 US disclosed
US-5179144-A Containing polysiloxane graft copolymer and organic silane; moldings with high impact strength at low temperature MITSUBISHI RAYON CO., LTD. (JP) 1993-01-12 US disclosed
EP-0488263-A2 Polyester resin compositions MITSUBISHI RAYON CO., LTD. (JP) 1992-06-03 EP disclosed
EP-0310097-B1 THERMOPLASTIC RESIN COMPOSITION MITSUBISHI RAYON CO., LTD. (JP) 1992-05-27 EP disclosed
EP-0476293-A1 Polyester resin compositions MITSUBISHI RAYON CO., LTD. (JP) 1992-03-25 EP disclosed
US-5084527-A Polyestersiloxane copolymers for impact strength MITSUBISHI RAYON CO., LTD. (JP) 1992-01-28 US disclosed
EP-0430134-A2 High impact graft copolymers and resin compositions MITSUBISHI RAYON CO., LTD. (JP) 1991-06-05 EP disclosed
EP-0384460-A1 Thermoplastic resin composition MITSUBISHI RAYON CO., LTD (JP) 1990-08-29 EP disclosed
US-4898918-A POLYETHERIMIDE, POLYESTERSILOXANE BLEND; IMPACT STRENGTH, HEAT RESISTANCE MITSUBISHI RAYON CO., LTD. (JP) 1990-02-06 US disclosed
US-4894427-A IMPACT STRENGTH MITSUBISHI RAYON CO., LTD. (JP) 1990-01-16 US disclosed
EP-0313852-A2 Aromatic polyester-polyorganosiloxane block copolymer MITSUBISHI RAYON CO., LTD. (JP) 1989-05-03 EP disclosed
EP-0310097-A1 Thermoplastic resin composition MITSUBISHI RAYON CO., LTD. (JP) 1989-04-05 EP disclosed