Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16428364 | 0.98 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KDM4EALDH1A1 | |
| SCHEMBL16426090 | 0.83 | LMNA (0.30) | — | |
| SCHEMBL16406619 | 0.82 | MEN1 (0.42) | SLC6A2SLC6A4SLC6A3KDM4EALDH1A1 | |
| SCHEMBL28667187 | 0.81 | KDM4E (0.37) | SLC6A2SLC6A4SLC6A3KDM4EALDH1A1 | |
| SCHEMBL16429329 | 0.80 | ALDH1A1 (0.38) | KDM4EALDH1A1 | |
| SCHEMBL8527153 | 0.79 | TP53 (0.38) | ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL18120342 | 0.79 | CHRNB4 (0.45) | SLC6A2SLC6A3KDM4EALDH1A1CHRNB4 | |
| SCHEMBL1357223 | 0.78 | TP53 (0.37) | CHRNB4CHRNA3 | |
| SCHEMBL18707182 | 0.78 | CHRNB4 (0.43) | SLC6A2SLC6A4SLC6A3KDM4EALDH1A1 | |
| SCHEMBL18707304 | 0.78 | CHRNB4 (0.43) | SLC6A2SLC6A4SLC6A3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643000-A2 | THERAPEUTIC PIPERAZINES | Dart Neuroscience (Cayman) Ltd (KY) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012040258-A2 | THERAPEUTIC PIPERAZINES | HELICON THERAPEUTICS, INC. (US) | 2012-03-29 | — | — | WO | disclosed |