SCHEMBL8736795

SCHEMBL8736795

Cc1ccc(Oc2ccccc2)c(C)c1C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 2/20 0.46
TSHR P16473 1/20 0.46
ALDH1A1 P00352 2/20 0.40
GAA P10253 2/20 0.40
RIPK1 Q13546 1/20 0.40
SLC6A2 P23975 1/20 0.40
SLC6A4 P31645 1/20 0.40
POLB P06746 1/20 0.40
CRHBP P24387 1/20 0.40
FNTA P49354 1/20 0.40
FNTB P49356 1/20 0.40
CRHR2 Q13324 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
MAPK1 P28482 1/20 0.40
HTT P42858 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
TTR P02766 4/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28926763 0.94 TTR (0.44) LTA4HTSHRALDH1A1GAAPOLB
SCHEMBL10006897 0.91 LTA4H (0.55) LTA4HTSHRALDH1A1GAARIPK1
SCHEMBL17628549 0.89 LTA4H (0.44) LTA4HTSHRALDH1A1GAARIPK1
SCHEMBL2339526 0.83 DHFR (0.54) LTA4HTSHRALDH1A1GAARIPK1
SCHEMBL30358266 0.83 DHFR (0.54) LTA4HTSHRALDH1A1GAARIPK1
SCHEMBL13475521 0.83 TEAD4 (0.45) ALDH1A1GAASLC6A4POLBCYP2C9
SCHEMBL12792086 0.83 HTT (0.53) LTA4HTSHRALDH1A1SLC6A4POLB
SCHEMBL31677108 0.82 LTA4H (0.41) LTA4HTSHRALDH1A1GAARIPK1
SCHEMBL18854378 0.81 NCEH1 (0.35) TSHRPOLBCYP1A2CYP3A4CYP2C19
SCHEMBL3331237 0.81 LTA4H (0.44) LTA4HTSHRALDH1A1GAARIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-56149433-A None JP disclosed
US-11758809-B2 Compound, display panel, and display apparatus Shanghai Tianma AM-OLED Co., Ltd. (CN) 2023-09-12 US disclosed
US-20120129893-A1 Inhibition Of Raf Kinase Using Substituted Heterocyclic Ureas DUMAS JACQUES (US) 2012-05-24 US disclosed
US-20120129893-A1 Inhibition Of Raf Kinase Using Substituted Heterocyclic Ureas DUMAS JACQUES (US) 2012-05-24 US disclosed
US-20070244120-A1 INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS BAYER HEALTHCARE LLC 2007-10-18 US disclosed
US-20070244120-A1 INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS BAYER HEALTHCARE LLC 2007-10-18 US disclosed
JP-S56149433-A POLYAMIDEIMIDE HAVING PHENOXAPHOSPHINE RING AND ITS PREPARATION OTSUKA CHEM CO LTD 1981-11-19 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070244120-A1 INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS BRAF, RAF1, ARAF LTA4H 4145/4885TSHR 2259/4885ALDH1A1 2759/4885
US-20120129893-A1 Inhibition Of Raf Kinase Using Substituted Heterocyclic Ureas BRAF, RAF1, ARAF LTA4H 4145/4885TSHR 2259/4885ALDH1A1 2759/4885
US-11758809-B2 Compound, display panel, and display apparatus C1S, C3AR1, DRD3 LTA4H 3086/4885TSHR 3170/4885ALDH1A1 928/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.