Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | BID | P55957 | 3/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.39 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.39 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8734866 | 1.00 | PPARA (0.42) | PPARATHRATHRBNR1H2NR1H3 | |
| Iodide SCHEMBL8736525 | 0.95 | DRD2 (0.41) | PPARATHRATHRBDRD2DRD1 | |
| Iodide SCHEMBL6941466 | 0.90 | THRA (0.48) | PPARATHRATHRBPPARGKCNH2 | |
| SCHEMBL8099840 | 0.88 | THRA (0.49) | PPARATHRATHRBPPARGKCNH2 | |
| SCHEMBL10180973 | 0.87 | THRA (0.47) | PPARATHRATHRBPPARGKCNH2 | |
| Iodide SCHEMBL8736416 | 0.85 | PTGDR2 (0.47) | THRATHRBDRD2DRD1DRD4 | |
| Iodide SCHEMBL9652564 | 0.84 | DRD2 (0.44) | PPARATHRATHRBDRD2DRD1 | |
| Iodide SCHEMBL8386680 | 0.84 | PPARA (0.46) | PPARATHRATHRBPPARGKCNH2 | |
| SCHEMBL2829914 | 0.83 | DRD2 (0.44) | PPARATHRATHRBDRD2DRD1 | |
| SCHEMBL14157502 | 0.82 | PPARA (0.47) | PPARATHRATHRBPPARGKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697387-B1 | Improved method for the preparation of iodonium salts | DOW CORNING (US) | 1998-04-22 | — | — | EP | disclosed |