Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.63 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | ADK | P55263 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15340847 | 0.82 | MKNK1 (0.43) | MAP4K4ABL1SRCMKNK1MKNK2 | |
| SCHEMBL624495 | 0.81 | MKNK1 (0.54) | MAP4K4MKNK1MKNK2TGFBR1NOS3 | |
| SCHEMBL15496384 | 0.79 | PDE4B (0.50) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL14881894 | 0.79 | RXRA (0.52) | KDRRXRARXRBRXRGNR4A2 | |
| SCHEMBL15340953 | 0.78 | ALOX5AP (0.47) | KDRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13524662 | 0.78 | ACVR1 (0.50) | FYNCREBBP | |
| SCHEMBL4582784 | 0.78 | MAP4K4 (0.69) | MAP4K4ABL1MKNK1MKNK2KDR | |
| SCHEMBL9177215 | 0.77 | RXRA (0.50) | KDRRXRARXRBRXRGBRD4 | |
| SCHEMBL398059 | 0.76 | ALDH1A1 (0.52) | ABL1SRCKDRRXRARXRB | |
| SCHEMBL18188070 | 0.76 | MAP4K4 (0.71) | MAP4K4MKNK1MKNK2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |