Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 10/20 | 0.75 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738264 | 0.91 | EZH2 (0.77) | EZH2PKML3MBTL1KMT2AMAPT | |
| SCHEMBL8738237 | 0.87 | EZH2 (0.81) | EZH2MAOBKMT2AMAPTMEN1 | |
| SCHEMBL8738962 | 0.87 | EZH2 (0.81) | EZH2PKML3MBTL1KMT2AMAPT | |
| SCHEMBL8738169 | 0.87 | EZH2 (0.74) | EZH2PKML3MBTL1KMT2AMAPT | |
| SCHEMBL7040302 | 0.87 | L3MBTL1 (0.76) | EZH2PKML3MBTL1KMT2AMAPT | |
| SCHEMBL8738221 | 0.86 | EZH2 (0.80) | EZH2L3MBTL1KMT2AMAPTMEN1 | |
| SCHEMBL8738997 | 0.86 | EZH2 (1.00) | EZH2KMT2AMAPTMEN1POLB | |
| SCHEMBL8738695 | 0.86 | EZH2 (0.91) | EZH2 | |
| SCHEMBL8738594 | 0.84 | EZH2 (0.77) | EZH2L3MBTL1KMT2AMAPTMEN1 | |
| SCHEMBL8739028 | 0.84 | EZH2 (0.80) | EZH2L3MBTL1KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |