D-Glutamate

D-Glutamate

SCHEMBL873822

N[C@H](CCC(=O)[O-])C(=O)[O-].[Ca+2]

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIN2D known ✓ O15399 1/20 0.41
GRIN3B known ✓ O60391 1/20 0.41
GRIN1 known ✓ Q05586 1/20 0.41
GRIN2A known ✓ Q12879 1/20 0.41
GRIN2B known ✓ Q13224 1/20 0.41
GRIN2C known ✓ Q14957 1/20 0.41
GRIN3A known ✓ Q8TCU5 1/20 0.41
CA1 P00915 2/20 0.48
BBOX1 O75936 1/20 0.41
GRM8 O00222 1/20 0.41
GRM6 O15303 1/20 0.41
GSR P00390 1/20 0.41
CYP1A2 P05177 1/20 0.41
GRIK1 P39086 1/20 0.41
GRM5 P41594 1/20 0.41
GRIA1 P42261 1/20 0.41
GRIA2 P42262 1/20 0.41
GRIA3 P42263 1/20 0.41
SLC1A3 P43003 1/20 0.41
SLC1A2 P43004 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
D-Glutamate SCHEMBL10341209 1.00 CA1 (0.48) CA1BBOX1GRM8GRM6GRIN2D
D-Glutamate SCHEMBL587123 1.00 CA1 (0.48) CA1BBOX1GRM8GRM6GRIN2D
D-Glutamate SCHEMBL10341208 1.00 CA1 (0.48) CA1BBOX1GRM8GRM6GRIN2D
D-Glutamate SCHEMBL587121 1.00 CA1 (0.48) CA1BBOX1GRM8GRM6GRIN2D
D-Glutamate SCHEMBL9650517 0.98 CA1 (0.46) CA1BBOX1GRM8GRM6GRIN2D
D-Glutamate SCHEMBL10881959 0.98 CA1 (0.46) CA1BBOX1GRM8GRM6GRIN2D
D-Glutamate SCHEMBL4383844 0.98 CA1 (0.46) CA1BBOX1GRM8GRM6GRIN2D
D-Glutamate SCHEMBL9243549 0.98 CA1 (0.46) CA1BBOX1GRM8GRM6GRIN2D
D-Glutamate SCHEMBL9243557 0.98 CA1 (0.46) CA1BBOX1GRM8GRM6GRIN2D
D-Glutamate SCHEMBL10341219 0.98 CA1 (0.46) CA1BBOX1GRM8GRM6GRIN2D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118716632-A Polypeptide composition for improving osteoporosis and enhancing bone density and preparation method thereof 海南华研美健生物科技有限公司 2024-10-01 CN claimed
CN-118160928-A Composition for promoting water supplementing and preparation method and application thereof 南京盛德创赢生物科技有限公司 2024-06-11 CN claimed
CN-113163808-A Fruit juice beverage with improved taste quality of sugar and sweetener 三得利控股株式会社 2021-07-23 CN claimed
CN-113163784-A Tea beverage with improved taste quality of sugar and sweetener 三得利控股株式会社 2021-07-23 CN claimed
CN-113163790-A Coffee beverage with improved taste quality of sugar and sweetener 三得利控股株式会社 2021-07-23 CN claimed
CN-113163814-A Flavored water with improved taste quality of sugar and sweetener 三得利控股株式会社 2021-07-23 CN claimed
CN-113163811-A Sparkling beverage with improved taste quality of sugar and sweetener 三得利控股株式会社 2021-07-23 CN claimed
WO-2020116633-A1 FRUIT JUICE BEVERAGE HAVING IMPROVED QUALITY OF TASTE EXHIBITED BY SUGAR AND SWEETENER サントリーホールディングス株式会社 2020-06-11 WO claimed
WO-2020116634-A1 FLAVOR WATER HAVING IMPROVED TASTE QUALITIES OF SUGAR AND SWEETENER サントリーホールディングス株式会社 2020-06-11 WO claimed
WO-2020116638-A1 COFFEE BEVERAGE HAVING IMPROVED QUALITY OF TASTE EXHIBITED BY SUGAR AND SWEETENER サントリーホールディングス株式会社 2020-06-11 WO claimed
WO-2020116641-A1 EFFERVESCENT BEVERAGE HAVING IMPROVED TASTE QUALITIES OF SUGAR AND SWEETENER サントリーホールディングス株式会社 2020-06-11 WO claimed
WO-2020116628-A1 TEA BEVERAGE IN WHICH QUALITY OF TASTE RESULTING FROM SUGARS AND SWEETENERS IS IMPROVED サントリーホールディングス株式会社 2020-06-11 WO claimed
EP-1735001-A2 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES COMPRISING A COMBINATION OF EPINASTINE AND ONE OR MORE ADDITIONAL MINERALS OR ONE OR MORE CRUDE DRUGS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-12-27 EP claimed
WO-2005089803-A2 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES COMPRISING A COMBINATION OF EPINASTINE AND ONE OR MORE ADDITIONAL MINERALS OR ONE OR MORE CRUDE DRUGS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2005-09-29 WO claimed
US-6858244-B2 Seasoning compositions, foods and drinks with the use thereof and processes for producing the same AJINOMOTO CO., INC. (JP) 2005-02-22 US claimed
US-20030198723-A1 Seasoning compositions, foods and drinks with the use thereof and processes for producing the same AJINOMOTO CO., INC. (JP) 2003-10-23 US claimed
EP-0081236-B1 A COMPOUND SEASONING COMPOSITION, A PROCESS FOR ITS PRODUCTION AND ITS USE AS A FOOD COMPONENT AJINOMOTO CO., INC. (JP) 1986-04-23 EP claimed
US-4563359-A MIXTURE OF GLUTAMIC ACID WITH SODIUM AND POTASSIUM SALTS AJINOMOTO COMPANY, LIMITED (JP) 1986-01-07 US claimed
EP-0081236-A1 A compound seasoning composition, a process for its production and its use as a food component AJINOMOTO CO., INC. (JP) 1983-06-15 EP claimed
JP-58098056-A None JP disclosed
CN-118716632-B Polypeptide composition for improving osteoporosis and enhancing bone density and preparation method thereof 海南华研美健生物科技有限公司 2024-12-06 CN disclosed
CN-118765982-A Stuffing-covered natural cheese 株式会社明治 2024-10-15 CN disclosed
CN-118716632-A Polypeptide composition for improving osteoporosis and enhancing bone density and preparation method thereof 海南华研美健生物科技有限公司 2024-10-01 CN disclosed
CN-118160928-A Composition for promoting water supplementing and preparation method and application thereof 南京盛德创赢生物科技有限公司 2024-06-11 CN disclosed
US-20240139226-A1 A COMPOSITION FOR PROMOTING GLP-1 SECRETION Hayashibara Co., Ltd. (JP) 2024-05-02 US disclosed
CN-113163811-B Sparkling beverage with improved taste quality exhibited by sugar and sweetener 三得利控股株式会社 2024-03-26 CN disclosed
EP-3491937-B1 LIQUID SEASONING AGENT CONTAINING SOLID INGREDIENTS MIZKAN HOLDINGS CO LTD (JP) 2024-02-28 EP disclosed
EP-4309515-A1 COMPOSITION FOR PROMOTING GLP-1 SECRETION Hayashibara Co., Ltd. (JP) 2024-01-24 EP disclosed
US-11578194-B2 Thickening composition improved in viscosity development TAIYO KAGAKU CO., LTD. (JP) 2023-02-14 US disclosed
WO-2022215619-A1 COMPOSITION FOR PROMOTING GLP-1 SECRETION 株式会社林原 2022-10-13 WO disclosed
CN-113277954-A Amino acid metal chelate micro-nano powder and preparation method thereof 英德市匠心新材料股份有限公司 2021-08-20 CN disclosed
CN-113163784-A Tea beverage with improved taste quality of sugar and sweetener 三得利控股株式会社 2021-07-23 CN disclosed
CN-113163814-A Flavored water with improved taste quality of sugar and sweetener 三得利控股株式会社 2021-07-23 CN disclosed
CN-113163790-A Coffee beverage with improved taste quality of sugar and sweetener 三得利控股株式会社 2021-07-23 CN disclosed
CN-113163808-A Fruit juice beverage with improved taste quality of sugar and sweetener 三得利控股株式会社 2021-07-23 CN disclosed
CN-113163811-A Sparkling beverage with improved taste quality of sugar and sweetener 三得利控股株式会社 2021-07-23 CN disclosed
CN-109479619-B Method for increasing content of 4-aminobutyric acid in pleurotus geesteranus sporocarp 浙江科技学院 2021-05-28 CN disclosed
WO-2020116628-A1 TEA BEVERAGE IN WHICH QUALITY OF TASTE RESULTING FROM SUGARS AND SWEETENERS IS IMPROVED サントリーホールディングス株式会社 2020-06-11 WO disclosed
WO-2020116638-A1 COFFEE BEVERAGE HAVING IMPROVED QUALITY OF TASTE EXHIBITED BY SUGAR AND SWEETENER サントリーホールディングス株式会社 2020-06-11 WO disclosed
WO-2020116634-A1 FLAVOR WATER HAVING IMPROVED TASTE QUALITIES OF SUGAR AND SWEETENER サントリーホールディングス株式会社 2020-06-11 WO disclosed
WO-2020116633-A1 FRUIT JUICE BEVERAGE HAVING IMPROVED QUALITY OF TASTE EXHIBITED BY SUGAR AND SWEETENER サントリーホールディングス株式会社 2020-06-11 WO disclosed
WO-2020116641-A1 EFFERVESCENT BEVERAGE HAVING IMPROVED TASTE QUALITIES OF SUGAR AND SWEETENER サントリーホールディングス株式会社 2020-06-11 WO disclosed
CN-105934158-B Tea beverage 麒麟饮料株式会社 2020-04-03 CN disclosed
EP-3491937-A1 LIQUID SEASONING AGENT CONTAINING SOLID INGREDIENTS Mizkan Holdings Co., Ltd. (JP) 2019-06-05 EP disclosed
US-20190150491-A1 LIQUID CONDIMENT CONTAINING SOLID INGREDIENT MIZKAN HOLDINGS CO., LTD. (JP) 2019-05-23 US disclosed
US-20180371212-A1 THICKENING COMPOSITION IMPROVED IN VISCOSITY DEVELOPMENT TAIYO KAGAKU CO., LTD. (JP) 2018-12-27 US disclosed
US-9375501-B2 Deodorant composition TAKASAGO INTERNATIONAL CORPORATION (JP) 2016-06-28 US disclosed
US-9358191-B2 Deodorant composition TAKASAGO INTERNATIONAL CORPORATION (JP) 2016-06-07 US disclosed
US-20140271522-A1 DEODORANT COMPOSITION TAKASAGO INTERNATIONAL CORPORATION (JP) 2014-09-18 US disclosed
EP-2067409-B1 THICKENING COMPOSITION IMPROVED IN VISCOSITY DEVELOPMENT TAIYO KAGAKU KK (JP) 2014-08-27 EP disclosed
US-8778320-B2 Deodorant composition TAKASAGO INTERNATIONAL CORPORATION (JP) 2014-07-15 US disclosed
EP-1561476-B1 DEODORANT COMPOSITION TAKASAGO PERFUMERY CO LTD (JP) 2014-02-12 EP disclosed
EP-2668852-A1 COMPOSITION FOR ORAL ADMINISTRATION FUJIFILM Corporation (JP) 2013-12-04 EP disclosed
US-20130309394-A1 COMPOSITION FOR ORAL ADMINISTRATION FUJIFILM CORPORATION (JP) 2013-11-21 US disclosed
EP-2618856-A1 DEODORANT COMPOSITION FOR SULFIDES Takasago International Corporation (JP) 2013-07-31 EP disclosed
US-20130136713-A1 DEODORANT COMPOSITION FOR SULFIDES TAKASAGO INTERNATIONAL CORPORATION (JP) 2013-05-30 US disclosed
US-8183409-B2 High yield and rapid synthesis methods for producing metallo-organic salts OSTEOLOGIX A/S (DK) 2012-05-22 US disclosed
WO-2012039516-A1 DEODORANT COMPOSITION FOR SULFIDES TAKASAGO INTERNATIONAL CORPORATION (JP) 2012-03-29 WO disclosed
EP-2241654-A2 Surface-treated metal material excelllent in resistance against galvanic corrosion and joined article of dissimilar materials including the surface-treated metal material Kabushiki Kaisha Kobe Seiko Sho (JP) 2010-10-20 EP disclosed
US-20100261024-A1 SURFACE-TREATED METAL MATERIAL EXCELLENT IN RESISTANCE AGAINST GALVANIC CORROSION AND JOINED ARTICLE OF DISSIMILAR MATERIALS INCLUDING THE SURFACE-TREATED METAL MATERIAL KABUSHIKI KAISHA KOBE SEIKO SHO (KOBE STEEL, LTD.) (JP) 2010-10-14 US disclosed
US-20100255146-A1 THICKENING COMPOSITION IMPROVED IN VISCOSITY DEVELOPMENT TAIYO KAGAKU CO., LTD. (JP) 2010-10-07 US disclosed
US-20100158840-A1 DEODORANT COMPOSITION TAKASAGO INTERNATIONAL CORPORATION (JP) 2010-06-24 US disclosed
US-20100019197-A1 DEOXIDANT COMPOSITION TAKASAGO INTERNATIONAL CORPORATION (JP) 2010-01-28 US disclosed
US-20090291926-A1 HIGH YIELD AND RAPID SYNTHESIS METHODS FOR PRODUCING METALLO-ORGANIC SALTS CHRISTGAU STEPHAN 2009-11-26 US disclosed
US-7589235-B2 High yield and rapid synthesis methods for producing metallo-organic salts OSTEOLOGIX, A/S (DK) 2009-09-15 US disclosed
US-20090087401-A1 DEODORANT COMPOSITION TAKASAGO INTERNATIONAL CORPORATION (JP) 2009-04-02 US disclosed
EP-2001435-A1 DEODORANT COMPOSITION Takasago International Corporation (JP) 2008-12-17 EP disclosed
US-20080230744-A1 Deoxidant Composition TAKASAGO INTERNATIONAL CORPORATION (JP) 2008-09-25 US disclosed
US-20070282127-A1 High Yield And Rapid Synthesis Methods For Producing Metallo-Organic Salts OSTEOLOGIX A/S 2007-12-06 US disclosed
WO-2007111362-A1 DEODORANT COMPOSITION TAKASAGO INTERNATIONAL CORPORATION (JP) 2007-10-04 WO disclosed
US-20070166256-A1 Hair cosmetic composition TAKASAO INTERNATIONAL CORPORATION (JP) 2007-07-19 US disclosed
EP-1744770-A2 HIGH YIELD AND RAPID SYNTHESES METHODS FOR PRODUCING METALLO-ORGANIC SALTS Osteologix A/S (DK) 2007-01-24 EP disclosed
EP-1743695-A1 OXYGEN ABSORBER COMPOSITION Takasago International Corporation (JP) 2007-01-17 EP disclosed
EP-1743620-A1 COSMETIC HAIR PREPARTION COMPOSITION Takasago International Corporation (JP) 2007-01-17 EP disclosed
EP-1735001-A2 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES COMPRISING A COMBINATION OF EPINASTINE AND ONE OR MORE ADDITIONAL MINERALS OR ONE OR MORE CRUDE DRUGS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-12-27 EP disclosed
US-20060165622-A1 Deodorant composition TAKASAGO INTERNATIONAL CORPORATION (JP) 2006-07-27 US disclosed
EP-0976399-B1 Process for the production of a propolis extract comprising an anion-exchange step HAYASHIBARA BIOCHEM LAB (JP) 2006-04-12 EP disclosed
WO-2005108339-A2 HIGH YIELD AND RAPID SYNTHESES METHODS FOR PRODUCING METALLO-ORGANIC SALTS OSTEOLOGIX A/S (DK) 2005-11-17 WO disclosed
WO-2005089803-A2 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES COMPRISING A COMBINATION OF EPINASTINE AND ONE OR MORE ADDITIONAL MINERALS OR ONE OR MORE CRUDE DRUGS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2005-09-29 WO disclosed
EP-1561476-A1 DEODORANT COMPOSITION Takasago International Corporation (JP) 2005-08-10 EP disclosed
US-20050084601-A1 Pumpkin for cooking use and process for producing the same AJINOMOTO CO. INC. (JP) 2005-04-21 US disclosed
US-6858244-B2 Seasoning compositions, foods and drinks with the use thereof and processes for producing the same AJINOMOTO CO., INC. (JP) 2005-02-22 US disclosed
US-20040126469-A1 Method of decreasing acrylamide in food cooked under heat TOYO SUISAN KAISHA, LTD. (JP) 2004-07-01 US disclosed
US-20030198723-A1 Seasoning compositions, foods and drinks with the use thereof and processes for producing the same AJINOMOTO CO., INC. (JP) 2003-10-23 US disclosed
EP-1277413-A1 SEASONING COMPOSITIONS, FOODS AND DRINKS WITH THE USE THEREOF AND PROCESS FOR PRODUCING THE SAME Ajinomoto Co., Inc. (JP) 2003-01-22 EP disclosed
US-20020045027-A1 Anti-fog resin sheet, anti-fog agent and method article DAINIPPON INK AND CHEMICALS, INC. (JP) 2002-04-18 US disclosed
EP-1184408-A2 Anti-fog resin sheet, anti-fog agent and molded article DAINIPPON INK AND CHEMICALS, INC. (JP) 2002-03-06 EP disclosed
EP-0909992-B1 Water-soluble photoresist composition FUJI CHEM IND CO LTD (JP) 2001-10-17 EP disclosed
US-6153228-A A DEODORIZED PROPOLIS EXTRACT WHEREIN THE AMOUNT OF AT LEAST ONE ODORIZING INGREDIENT IS REDUCED; TESTING USING GAS CHROMATOGRAPHY; COSMETICS; DRUGS; FOODS KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2000-11-28 US disclosed
US-6153227-A REDUCING THE ODOR BY SOAKING PROPOLIS IN A HYDROPHILIC SOLVENT, E.G., METHANOL, TO EFFECT EXTRACTION FOLLOWED BY TREATING THE LIQUID LAYER WITH AN ANION EXCHANGE RESIN; WITHOUT ATTENUATING THE INHERENT BIOLOGICAL ACTIVITIES KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2000-11-28 US disclosed
EP-0976399-A1 Propolis extract KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2000-02-02 EP disclosed
EP-0909992-A1 Water-soluble photoresist composition Fuji Chemicals Industrial Co., Ltd. (JP) 1999-04-21 EP disclosed
US-5268279-A Culture of Bacillus microorganisms TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-12-07 US disclosed
EP-0410638-A2 Method for producing polyglutamic acid or a salt thereof Takeda Chemical Industries, Ltd. (JP) 1991-01-30 EP disclosed
EP-0125021-B1 SEASONING COMPOSITION Takeda Chemical Industries, Ltd. (JP) 1987-07-08 EP disclosed
EP-0081236-B1 A COMPOUND SEASONING COMPOSITION, A PROCESS FOR ITS PRODUCTION AND ITS USE AS A FOOD COMPONENT AJINOMOTO CO., INC. (JP) 1986-04-23 EP disclosed
US-4563359-A MIXTURE OF GLUTAMIC ACID WITH SODIUM AND POTASSIUM SALTS AJINOMOTO COMPANY, LIMITED (JP) 1986-01-07 US disclosed
EP-0125021-A1 Seasoning composition Takeda Chemical Industries, Ltd. (JP) 1984-11-14 EP disclosed
EP-0081236-A1 A compound seasoning composition, a process for its production and its use as a food component AJINOMOTO CO., INC. (JP) 1983-06-15 EP disclosed
JP-S5898056-A ASSORTED SEASONING COMPOSITION AND ITS PREPARATION AJINOMOTO CO INC 1983-06-10 JP disclosed
JP-S5898056-A ASSORTED SEASONING COMPOSITION AND ITS PREPARATION AJINOMOTO CO INC 1983-06-10 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240139226-A1 A COMPOSITION FOR PROMOTING GLP-1 SECRETION IAPP, GLP1R, B3GNT2 GRIN2D 4069/4885GRIN3B 2416/4885GRIN1 1116/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.