Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 5/20 | 0.39 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL882629 | 0.89 | CHRNA7 (0.42) | CHRNA7SYKTRPV1KDM4EHPGD | |
| SCHEMBL874291 | 0.88 | CHRNA7 (0.39) | CHRNA7SYKTRPV1KDM4EHPGD | |
| SCHEMBL874835 | 0.87 | MEN1 (0.43) | CHRNA7CSF1RROCK2KDM4EHPGD | |
| SCHEMBL874210 | 0.87 | MAPT (0.40) | CHRNA7CSF1RROCK2KDM4EHPGD | |
| SCHEMBL873721 | 0.84 | BCHE (0.39) | CHRNA7SYKTRPV1BCHEACHE | |
| SCHEMBL875500 | 0.83 | ATR (0.41) | CHRNA7SYKNAMPT | |
| SCHEMBL873722 | 0.83 | RXFP1 (0.38) | CHRNA7SYKTRPV1KDM4EHPGD | |
| SCHEMBL875501 | 0.82 | CHRNA7 (0.40) | CHRNA7SYKTRPV1KDM4EHPGD | |
| SCHEMBL875385 | 0.77 | MAPT (0.40) | CHRNA7CSF1RKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL874339 | 0.76 | MKNK1 (0.39) | CHRNA7CSF1RTRPV1ROCK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |