Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874210 | 0.86 | MAPT (0.40) | RIPK1MAPTCHRNA7ROCK2ROCK1 | |
| SCHEMBL874058 | 0.83 | NAMPT (0.42) | MKNK2CHRNA7NAMPTNPSR1DYRK1A | |
| SCHEMBL874059 | 0.82 | NAMPT (0.41) | MKNK1MKNK2MAPTCHRNA7NPC1 | |
| SCHEMBL874835 | 0.78 | MEN1 (0.43) | MAPTCHRNA7ROCK2GAANPC1 | |
| SCHEMBL874680 | 0.76 | NPC1 (0.46) | MAPTTP53GAANPC1RAB9A | |
| SCHEMBL873877 | 0.76 | CHRNA7 (0.42) | RIPK1MAPTCHRNA7ROCK2NPC1 | |
| SCHEMBL875385 | 0.76 | MAPT (0.40) | MAPTCHRNA7ROCK1TP53NPC1 | |
| SCHEMBL874837 | 0.75 | KMT2A (0.37) | MAPTCHRNA7ROCK1NPC1RAB9A | |
| SCHEMBL874570 | 0.74 | MOK (0.43) | MAPTCHRNA7ROCK1TP53NPC1 | |
| SCHEMBL874246 | 0.74 | PDE4B (0.44) | MAPTCHRNA7TP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |