Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLPP | Q16740 | 19/20 | 0.81 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.78 |
| ▸ | TCF7 | P36402 | 2/20 | 0.78 |
| ▸ | BCL9 | O00512 | 1/20 | 0.78 |
| ▸ | TCF4 | P15884 | 1/20 | 0.78 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17831045 | 0.94 | CLPP (0.85) | CLPPCTNNB1TCF7BCL9TCF4 | |
| SCHEMBL12485555 | 0.94 | CLPP (0.85) | CLPPCTNNB1TCF7BCL9TCF4 | |
| SCHEMBL14843605 | 0.93 | CLPP (0.77) | CLPPCTNNB1TCF7BCL9TCF4 | |
| SCHEMBL17831039 | 0.93 | CLPP (0.77) | CLPPCTNNB1TCF7BCL9TCF4 | |
| SCHEMBL15341559 | 0.92 | CLPP (0.75) | CLPPCTNNB1TCF7BCL9TCF4 | |
| SCHEMBL12485186 | 0.92 | CLPP (0.75) | CLPPCTNNB1TCF7BCL9TCF4 | |
| SCHEMBL17831042 | 0.92 | CLPP (0.75) | CLPPCTNNB1TCF7BCL9TCF4 | |
| SCHEMBL14843015 | 0.92 | CLPP (0.75) | CLPPCTNNB1TCF7BCL9TCF4 | |
| SCHEMBL14843055 | 0.92 | CLPP (0.75) | CLPPCTNNB1TCF7BCL9TCF4 | |
| SCHEMBL17831040 | 0.92 | CLPP (0.75) | CLPPCTNNB1TCF7BCL9TCF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371330-B2 | Substituted pyrazino[1,2-a]pyrimidines useful as CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150232468-A1 | CBP/CATENIN ANTAGONISTS FOR ENHANCING ASYMMETRIC DIVISION OF SOMATIC STEM CELLS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2015-08-20 | — | — | US | disclosed |
| US-20130280233-A1 | CBP/CATENIN ANTAGONISTS FOR ENHANCING ASYMMETRIC DIVISION OF SOMATIC STEM CELLS | UNIVERSITY OF SOUTHERN CALIFORNIA | 2013-10-24 | — | — | US | disclosed |
| WO-2012068299-A2 | CBP/CATENIN ANTAGONISTS FOR ENHANCING ASYMMETRIC DIVISION OF SOMATIC STEM CELLS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232468-A1 | CBP/CATENIN ANTAGONISTS FOR ENHANCING ASYMMETRIC DIVISION OF SOMATIC STEM CELLS | WNT3A, CTNNB1, WNT1 | CLPP 3505/4885CTNNB1 2/4885TCF7 331/4885 |
| US-20130280233-A1 | CBP/CATENIN ANTAGONISTS FOR ENHANCING ASYMMETRIC DIVISION OF SOMATIC STEM CELLS | WNT3A, WNT1, CTNNA1 | CLPP 3416/4885CTNNB1 4/4885TCF7 296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.