SCHEMBL8739191

SCHEMBL8739191

CON(C)C(=O)c1ccc2cc(NC(=O)OC(C)(C)C)ccc2c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 2/20 0.44
KAT6A Q92794 1/20 0.43
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA9 Q16790 1/20 0.41
NAMPT P43490 1/20 0.41
NPC1 O15118 3/20 0.40
RAB9A P51151 3/20 0.40
HDAC3 O15379 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
PRMT3 O60678 1/20 0.40
PLAU P00749 1/20 0.40
ALDH1A1 P00352 2/20 0.39
GAA P10253 1/20 0.39
MLYCD O95822 1/20 0.39
KDM4E B2RXH2 1/20 0.39
LEF1 Q9UJU2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8739566 0.87 CYP17A1 (0.49) CYP17A1CA12CA1CA9NAMPT
SCHEMBL8109929 0.85 HDAC3 (0.55) CYP17A1KAT6ACA12CA1CA9
SCHEMBL3563135 0.83 PTPN11 (0.54) CYP17A1KAT6ACA12CA1CA9
SCHEMBL6113073 0.81 KAT6A (0.48) CYP17A1KAT6ACA12CA1CA9
SCHEMBL4672586 0.80 NPC1 (0.50) KAT6ACA12CA1CA9NPC1
SCHEMBL6125423 0.80 KAT6A (0.43) CYP17A1KAT6ACA12CA1CA9
SCHEMBL3564415 0.79 ALDH1A1 (0.51) CYP17A1KAT6ACA12CA1CA9
SCHEMBL6113230 0.79 MAPT (0.46) CYP17A1KAT6ACA12CA1CA9
SCHEMBL3567785 0.79 CYP17A1 (0.49) CYP17A1KAT6ACA12CA1CA9
SCHEMBL9102483 0.79 MLYCD (0.40) CYP17A1CA12CA1CA9HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9006458-B2 Surface Enhanced Raman Spectroscopy (SERS) compounds and methods of their preparation AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2015-04-14 US disclosed
US-9006458-B2 Surface Enhanced Raman Spectroscopy (SERS) compounds and methods of their preparation AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2015-04-14 US disclosed
US-20120128592-A1 SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) COMPOUNDS AND METHODS OF THEIR PREPARATION AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2012-05-24 US disclosed
US-20120128592-A1 SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) COMPOUNDS AND METHODS OF THEIR PREPARATION AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2012-05-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120128592-A1 SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) COMPOUNDS AND METHODS OF THEIR PREPARATION NR1I2, SPR, NR1H4 CYP17A1 211/4885KAT6A 3865/4885CA12 796/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.