Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.56 |
| ▸ | IDO1 | P14902 | 3/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9303119 | 0.88 | FAAH (0.60) | HDAC1HDAC6HRH3IDO1KMT2A | |
| SCHEMBL8739201 | 0.82 | HDAC1 (0.61) | HDAC1HDAC6HRH3IDO1SMN1; SMN2 | |
| SCHEMBL3725969 | 0.82 | HDAC1 (0.55) | HDAC1HDAC6HRH3KMT2ATP53 | |
| SCHEMBL12850040 | 0.81 | HDAC6 (1.00) | HDAC1HDAC6IDO1SMN1; SMN2LMNA | |
| Tert-Butyl Formate SCHEMBL27786473 | 0.80 | HDAC1 (0.53) | HDAC1HDAC6HRH3IDO1SMN1; SMN2 | |
| SCHEMBL4937775 | 0.79 | HTT (0.51) | HDAC1HDAC6HRH3IDO1SMN1; SMN2 | |
| SCHEMBL4943222 | 0.78 | USP30 (0.56) | HDAC1HDAC6HRH3 | |
| SCHEMBL4943219 | 0.78 | USP30 (0.56) | HDAC1HDAC6HRH3 | |
| SCHEMBL9303184 | 0.78 | CYP11B1 (0.51) | HDAC1HDAC6HRH3GAASMN1; SMN2 | |
| SCHEMBL4937782 | 0.76 | LMNA (0.54) | HDAC1HDAC6HRH3IDO1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314880-A | Platelet activating factor antagonist | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1994-05-24 | — | — | US | disclosed |
| EP-0468971-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |
| WO-1990009997-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1990-09-07 | — | — | WO | disclosed |