Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | HTR1D | P28221 | 2/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873945 | 1.00 | DRD2 (0.45) | DRD2DRD3HTR1DSCN9ASCN5A | |
| SCHEMBL4517409 | 0.88 | DRD2 (0.44) | DRD2DRD3HTR1DSCN9ASCN5A | |
| SCHEMBL4517412 | 0.88 | DRD2 (0.44) | DRD2DRD3HTR1DSCN9ASCN5A | |
| SCHEMBL6645022 | 0.84 | DRD2 (0.54) | DRD2DRD3HTR1DDRD4HTR5A | |
| SCHEMBL28356770 | 0.83 | MTNR1A (0.45) | DRD2 | |
| SCHEMBL8823791 | 0.81 | DRD2 (0.48) | DRD2DRD3HTR1DSCN9ASCN5A | |
| SCHEMBL19667663 | 0.81 | EPHX2 (0.43) | SCN9ASCN5AKCNH2KMT2AL3MBTL1 | |
| SCHEMBL4788156 | 0.80 | SCN9A (0.44) | SCN9ASCN5AKCNH2 | |
| SCHEMBL4788147 | 0.80 | SCN9A (0.44) | SCN9ASCN5AKCNH2 | |
| SCHEMBL19667244 | 0.79 | KMT2A (0.47) | KMT2AL3MBTL1KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012039657-A1 | NOVEL CHROMANE COMPOUND FOR THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2012-03-29 | — | — | WO | disclosed |