Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788156 | 1.00 | SCN9A (0.44) | SCN9ASCN5AKCNH2KDM4DRORC | |
| SCHEMBL873946 | 0.80 | DRD2 (0.45) | SCN9ASCN5AKCNH2 | |
| SCHEMBL873945 | 0.80 | DRD2 (0.45) | SCN9ASCN5AKCNH2 | |
| SCHEMBL4749973 | 0.78 | METAP2 (0.35) | SCN9ASCN5A | |
| SCHEMBL4749974 | 0.78 | METAP2 (0.35) | SCN9ASCN5A | |
| SCHEMBL28356770 | 0.78 | MTNR1A (0.45) | — | |
| SCHEMBL4750961 | 0.77 | SCN9A (0.65) | SCN9ASCN5AKCNH2 | |
| SCHEMBL4749709 | 0.77 | SCN9A (0.65) | SCN9ASCN5AKCNH2 | |
| SCHEMBL4750448 | 0.76 | SCN9A (0.51) | SCN9ASCN5AKCNH2 | |
| SCHEMBL4750450 | 0.76 | SCN9A (0.51) | SCN9ASCN5AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |