Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 6/20 | 0.53 |
| ▸ | ITK | Q08881 | 6/20 | 0.53 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.51 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23221371 | 0.80 | PCSK9 (0.55) | LCKITKUSP30OTUD7BROCK2 | |
| SCHEMBL13457496 | 0.78 | SMN1; SMN2 (0.62) | LCKITKUSP30OTUD7BROCK2 | |
| SCHEMBL13457222 | 0.77 | LCK (0.62) | LCKITKUSP30MAP4K1ABL1 | |
| SCHEMBL6068368 | 0.77 | ABL1 (0.71) | LCKITKROCK2PIK3CGABL1 | |
| SCHEMBL20055849 | 0.74 | USP30 (0.44) | LCKITKUSP30OTUD7BROCK2 | |
| SCHEMBL13457481 | 0.73 | ROCK2 (0.64) | LCKITKUSP30OTUD7BROCK2 | |
| SCHEMBL13457179 | 0.73 | SCD (0.72) | LCKITKROCK2 | |
| SCHEMBL19302828 | 0.72 | ROCK2 (0.56) | LCKITKROCK2PCSK9 | |
| SCHEMBL19031537 | 0.72 | ALKBH5 (0.62) | PIK3CGPIK3CA | |
| SCHEMBL13457003 | 0.71 | LCK (0.53) | LCKITKUSP30OTUD7BROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068546-A1 | HETEROCYCLE AMINES AND USES THEREOF | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |