Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874686 | 0.89 | CYP3A4 (0.42) | DRD2DRD3KCNH2CHRNA7NAMPT | |
| SCHEMBL874016 | 0.85 | NAMPT (0.37) | DRD2DRD3KCNH2CHRNA7NAMPT | |
| SCHEMBL873657 | 0.84 | CYP3A4 (0.41) | DRD2DRD3KCNH2CHRNA7NAMPT | |
| SCHEMBL874151 | 0.81 | CYP3A4 (0.40) | DRD2DRD3KCNH2CHRNA7NAMPT | |
| SCHEMBL486239 | 0.81 | KCNH2 (0.43) | KCNH2CHRNA7IKBKBKDRKDM5B | |
| SCHEMBL874515 | 0.81 | ATR (0.43) | DRD2DRD3KCNH2CHRNA7NAMPT | |
| SCHEMBL874058 | 0.81 | NAMPT (0.42) | DRD2DRD3KCNH2CHRNA7NAMPT | |
| SCHEMBL486210 | 0.80 | NAMPT (0.51) | KCNH2CHRNA7NAMPTTGFBR1TGFBR2 | |
| SCHEMBL873820 | 0.80 | ATR (0.46) | DRD2DRD3KCNH2CHRNA7NAMPT | |
| SCHEMBL485807 | 0.79 | TGFBR1 (0.40) | KCNH2CHRNA7NAMPTIKBKBKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |