Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | TK1 | P04183 | 3/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | TK2 | O00142 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8663347 | 0.86 | TK1 (0.42) | LMNASMN1; SMN2ALOX12ADRA1ATK1 | |
| SCHEMBL17409471 | 0.78 | TK1 (0.44) | LMNASMN1; SMN2ALOX12ADRA1ATK1 | |
| SCHEMBL17124833 | 0.78 | TK1 (0.44) | LMNASMN1; SMN2ALOX12ADRA1ATK1 | |
| SCHEMBL25492408 | 0.78 | TK1 (0.44) | LMNASMN1; SMN2ALOX12ADRA1ATK1 | |
| SCHEMBL17403368 | 0.78 | TK1 (0.44) | LMNASMN1; SMN2ALOX12ADRA1ATK1 | |
| SCHEMBL5705312 | 0.78 | LMNA (0.46) | LMNASMN1; SMN2ALOX12ADRA1ATK1 | |
| SCHEMBL25809594 | 0.75 | TK1 (0.45) | LMNASMN1; SMN2ALOX12ADRA1ATK1 | |
| SCHEMBL16378861 | 0.71 | LMNA (0.49) | LMNASMN1; SMN2ALOX12ADRA1ATK1 | |
| SCHEMBL29388908 | 0.71 | LMNA (0.49) | LMNASMN1; SMN2ALOX12ADRA1ATK1 | |
| SCHEMBL6910650 | 0.71 | LMNA (0.44) | LMNASMN1; SMN2ALOX12ADRA1ATK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101516389-A | Combination therapy for the treatment of viral infections | UNITED THERAPEUTICS CORP (US) | 2009-08-26 | — | — | CN | disclosed |
| EP-0594677-A4 | ANTIVIRAL LIPONUCLEOSIDES: TREATMENT OF HEPATITIS B | VICAL INC (US) | 1997-09-17 | — | — | EP | disclosed |
| EP-0594677-A1 | ANTIVIRAL LIPONUCLEOSIDES: TREATMENT OF HEPATITIS B | NeXstar Pharmaceuticals, Inc. (US) | 1994-05-04 | — | — | EP | disclosed |
| WO-1993000910-A1 | ANTIVIRAL LIPONUCLEOSIDES: TREATMENT OF HEPATITIS B | VICAL, INC. (US) | 1993-01-21 | — | — | WO | disclosed |