Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 3/20 | 0.77 |
| ▸ | F2 | P00734 | 2/20 | 0.77 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.77 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.77 |
| ▸ | PLAU | P00749 | 1/20 | 0.77 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.77 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.77 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.77 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.77 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.77 |
| ▸ | F10 | P00742 | 1/20 | 0.77 |
| ▸ | PLG | P00747 | 1/20 | 0.77 |
| ▸ | S100B | P04271 | 1/20 | 0.77 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.77 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.77 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.77 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.77 |
| ▸ | AOC1 | P19801 | 1/20 | 0.77 |
| ▸ | MAOA | P21397 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12348100 | 1.00 | PRMT1 (0.77) | PRMT1F2ST14TMPRSS2PLAU | |
| Pentamidine Dao SCHEMBL12348101 | 0.92 | GAA (0.84) | PRMT1F2ST14TMPRSS2PLAU | |
| SCHEMBL14599580 | 0.92 | GAA (0.84) | PRMT1F2ST14TMPRSS2PLAU | |
| Pentamidine Dao SCHEMBL12355833 | 0.92 | GAA (0.84) | PRMT1F2ST14TMPRSS2PLAU | |
| SCHEMBL14599648 | 0.92 | GAA (0.84) | PRMT1F2ST14TMPRSS2PLAU | |
| SCHEMBL14599647 | 0.92 | GAA (0.84) | PRMT1F2ST14TMPRSS2PLAU | |
| SCHEMBL14599579 | 0.92 | GAA (0.84) | PRMT1F2ST14TMPRSS2PLAU | |
| Pentamidine Dao SCHEMBL8653348 | 0.92 | GAA (0.84) | PRMT1F2ST14TMPRSS2PLAU | |
| Pentamidine SCHEMBL3329 | 0.88 | PRMT1 (1.00) | PRMT1F2ST14TMPRSS2PLAU | |
| Hexamidine SCHEMBL144738 | 0.88 | PRMT1 (1.00) | PRMT1F2ST14TMPRSS2PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524732-B2 | Substituted tetrahydroquinolines | MERCK PATENT GMBH (DE) | 2013-09-03 | — | — | US | disclosed |
| EP-2121700-B1 | SUBSTITUTED TETRAHYDROQUINOLINES | MERCK PATENT GMBH (DE) | 2012-10-03 | — | — | EP | disclosed |
| US-20120130147-A1 | METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS | FINSINGER DIRK (DE) | 2012-05-24 | — | — | US | disclosed |
| US-8110583-B2 | treatment of tumors; 1,5-bis(4'-(N-hydroxyamidino)phenoxy)pentane; maintain cells in the G2/M cell cycle | MERCK PATENT GMBH (DE) | 2012-02-07 | — | — | US | disclosed |
| US-7994225-B2 | Combination of an antibiotic and a drug such as pentamidine or salts thereof to treat drug resistant eye and ear infections | REMPEX PHARMACEUTICALS, INC. (US) | 2011-08-09 | — | — | US | disclosed |
| US-7947741-B2 | Use and administration of bacterial efflux pump inhibitors | MPEX PHARMACEUTICALS, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-7875614-B2 | compounds for treatment of tumors | MERCK PATENT GMBH (DE) | 2011-01-25 | — | — | US | disclosed |
| EP-1891011-B1 | TETRAHYDROQUINOLINES USED IN THE FORM OF MODULATORS OF MITOTIC MOTOR-PROTEINS EG5 | MERCK PATENT GMBH (DE) | 2010-12-08 | — | — | EP | disclosed |
| EP-2033959-A1 | Tetrahydropyranoquinoline derivatives | Merck Patent GmbH (DE) | 2009-03-11 | — | — | EP | disclosed |
| WO-2008113451-A1 | SUBSTITUTED TETRAHYDROQUINOLINES | MERCK PATENT GMBH (DE) | 2008-09-25 | — | — | WO | disclosed |
| WO-2007041677-A9 | SOFT TISSUE IMPLANTS AND DRUG COMBINATION COMPOSITIONS, AND USE THEREOF | COMBINATORX INC (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007054138-A1 | SUBSTITUTED TETRAHYDROQUINOLINES | MERCK PATENT GMBH (DE) | 2007-05-18 | — | — | WO | disclosed |
| US-20070099905-A1 | Combinations of drugs for the treatment of neoplasms | BORISY ALEXIS | 2007-05-03 | — | — | US | disclosed |
| US-20070099906-A1 | Combinations for the treatment of noeplastic disorders | COMBINATORX, INC. | 2007-05-03 | — | — | US | disclosed |
| US-20070099906-A1 | Combinations for the treatment of noeplastic disorders | COMBINATORX, INC. | 2007-05-03 | — | — | US | disclosed |
| US-20070099905-A1 | Combinations of drugs for the treatment of neoplasms | BORISY ALEXIS | 2007-05-03 | — | — | US | disclosed |
| WO-2007041677-A2 | SOFT TISSUE IMPLANTS AND DRUG COMBINATION COMPOSITIONS, AND USE THEREOF | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007041593-A2 | ANTI-SCARRING DRUG COMBINATIONS AND USE THEREOF | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007041584-A2 | IMPLANTABLE SENSORS, IMPLANTABLE PUMPS, AND ANTI-SCARRING DRUG COMBINATIONS | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007041463-A2 | ELECTRICAL DEVICES AND ANTI-SCARRING DRUG COMBINATIONS | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130147-A1 | METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS | TP53, IDH3A, IDH2 | PRMT1 26/4885F2 512/4885ST14 1883/4885 |
| US-20070099905-A1 | Combinations of drugs for the treatment of neoplasms | VHL, NRAS, MYC | PRMT1 2584/4885F2 2085/4885ST14 508/4885 |
| US-20070099906-A1 | Combinations for the treatment of noeplastic disorders | NOP56, XPOT, NPM1 | PRMT1 406/4885F2 2263/4885ST14 2830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.