Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 4/20 | 0.53 |
| ▸ | MMP8 | P22894 | 4/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
| ▸ | MME | P08473 | 4/20 | 0.50 |
| ▸ | ACE | P12821 | 3/20 | 0.50 |
| ▸ | CPA1 | P15085 | 2/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 3/20 | 0.49 |
| ▸ | FCER2 | P06734 | 3/20 | 0.49 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 3/20 | 0.47 |
| ▸ | CTSS | P25774 | 3/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8740506 | 0.91 | MMP9 (0.56) | MMP9MMP8OPRD1MMEACE | |
| SCHEMBL8740489 | 0.88 | MMP9 (0.51) | MMP9MMP8OPRD1MMEACE | |
| SCHEMBL26426392 | 0.87 | FCER2 (0.58) | MMP9MMP8MMEACECPA1 | |
| SCHEMBL13126115 | 0.86 | FCER2 (0.53) | MMP9MMP8MMEACECPA1 | |
| SCHEMBL13125899 | 0.86 | CTSB (0.47) | MMP9MMP8OPRD1MMEACE | |
| SCHEMBL8740501 | 0.86 | CTSB (0.53) | MMP9MMP8OPRD1MMEACE | |
| SCHEMBL13125726 | 0.85 | CYP1A2 (0.51) | MMP9MMP8MMEACECPA1 | |
| SCHEMBL14401071 | 0.84 | MMP9 (0.49) | MMP9MMP8OPRD1MMEACE | |
| SCHEMBL14401100 | 0.84 | MMP9 (0.52) | MMP9MMP8OPRD1MMEACE | |
| SCHEMBL6020847 | 0.83 | CTSB (0.53) | MMP9MMP8OPRD1MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5629285-A | Inhibitors of TNF-α secretion | IMMUNEX CORPORATION (US) | 1997-05-13 | — | — | US | disclosed |
| EP-0715619-A4 | INHIBITORS OF TNF-ALPHA SECRETION | IMMUNEX CORP (US) | 1997-03-19 | — | — | EP | disclosed |
| US-5594106-A | Inhibitors of TNF-α secretion | IMMUNEX CORPORATION (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0715619-A1 | INHIBITORS OF TNF-ALPHA SECRETION | IMMUNEX CORPORATION (US) | 1996-06-12 | — | — | EP | disclosed |
| WO-1995006031-A1 | INHIBITORS OF TNF-ALPHA SECRETION | IMMUNEX CORPORATION (US) | 1995-03-02 | — | — | WO | disclosed |