Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 3/20 | 0.53 |
| ▸ | CTSS | P25774 | 3/20 | 0.53 |
| ▸ | CTSK | P43235 | 2/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 6/20 | 0.46 |
| ▸ | MMP8 | P22894 | 5/20 | 0.46 |
| ▸ | MMP2 | P08253 | 4/20 | 0.46 |
| ▸ | REN | P00797 | 1/20 | 0.45 |
| ▸ | FCER2 | P06734 | 3/20 | 0.44 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 2/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | CPA1 | P15085 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | IDE | P14735 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8740498 | 0.88 | CTSS (0.68) | CTSBCTSSCTSKOPRD1MMP9 | |
| SCHEMBL5556443 | 0.88 | CTSS (0.68) | CTSBCTSSCTSKOPRD1MMP9 | |
| SCHEMBL8740516 | 0.86 | MMP9 (0.53) | CTSBCTSSCTSKOPRD1MMP9 | |
| SCHEMBL8740506 | 0.86 | MMP9 (0.56) | OPRD1MMP9MMP8MMP2FCER2 | |
| SCHEMBL8740489 | 0.82 | MMP9 (0.51) | CTSBCTSSCTSKOPRD1MMP9 | |
| SCHEMBL8593007 | 0.80 | CTSB (0.52) | CTSBCTSSCTSKMMP9MMP8 | |
| SCHEMBL8740495 | 0.79 | CTSS (0.72) | CTSBCTSSCTSKMMP9MMP8 | |
| SCHEMBL7655882 | 0.77 | CTSS (0.69) | CTSBCTSSCTSKMMP9MMP8 | |
| SCHEMBL9331930 | 0.77 | CTSS (0.69) | CTSBCTSSCTSKMMP9MMP8 | |
| SCHEMBL8740509 | 0.77 | CTSS (0.69) | CTSBCTSSCTSKMMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5629285-A | Inhibitors of TNF-α secretion | IMMUNEX CORPORATION (US) | 1997-05-13 | — | — | US | disclosed |
| EP-0715619-A4 | INHIBITORS OF TNF-ALPHA SECRETION | IMMUNEX CORP (US) | 1997-03-19 | — | — | EP | disclosed |
| US-5594106-A | Inhibitors of TNF-α secretion | IMMUNEX CORPORATION (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0715619-A1 | INHIBITORS OF TNF-ALPHA SECRETION | IMMUNEX CORPORATION (US) | 1996-06-12 | — | — | EP | disclosed |
| WO-1995006031-A1 | INHIBITORS OF TNF-ALPHA SECRETION | IMMUNEX CORPORATION (US) | 1995-03-02 | — | — | WO | disclosed |