Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.49 |
| ▸ | PREP | P48147 | 1/20 | 0.46 |
| ▸ | FAP | Q12884 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4968150 | 1.00 | DPP4 (0.51) | DPP4DPP8DPP9DPP7PREP | |
| Fumaric Acid SCHEMBL2932668 | 1.00 | DPP4 (0.51) | DPP4DPP8DPP9DPP7PREP | |
| Fumaric Acid SCHEMBL1038512 | 1.00 | DPP4 (0.51) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL29918628 | 0.95 | DPP4 (0.54) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL195631 | 0.95 | DPP4 (0.54) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL2553750 | 0.95 | DPP4 (0.54) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL14634591 | 0.93 | DPP4 (0.51) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL989161 | 0.93 | DPP4 (0.51) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL1436475 | 0.89 | DPP4 (0.62) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL665960 | 0.89 | DPP4 (0.62) | DPP4DPP8DPP9DPP7PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966193-A1 | NEW SALT AND POLYMORPH OF DPP-IV INHIBITOR | F. Hoffmann-la Roche AG (CH) | 2008-09-10 | — | — | EP | claimed |
| WO-2007071576-A1 | NEW SALT AND POLYMORPH OF DPP-IV INHIBITOR | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-28 | — | — | WO | claimed |
| WO-2011127051-A1 | MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-10-13 | — | — | WO | disclosed |
| EP-1966193-A1 | NEW SALT AND POLYMORPH OF DPP-IV INHIBITOR | F. Hoffmann-la Roche AG (CH) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071576-A1 | NEW SALT AND POLYMORPH OF DPP-IV INHIBITOR | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-28 | — | — | WO | disclosed |