Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 19/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.49 |
| ▸ | PREP | P48147 | 1/20 | 0.46 |
| ▸ | FAP | Q12884 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4968150 | 1.00 | DPP4 (0.51) | DPP4DPP8DPP9DPP7PREP | |
| Fumaric Acid SCHEMBL874060 | 1.00 | DPP4 (0.51) | DPP4DPP8DPP9DPP7PREP | |
| Fumaric Acid SCHEMBL1038512 | 1.00 | DPP4 (0.51) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL29918628 | 0.95 | DPP4 (0.54) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL195631 | 0.95 | DPP4 (0.54) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL2553750 | 0.95 | DPP4 (0.54) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL14634591 | 0.93 | DPP4 (0.51) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL989161 | 0.93 | DPP4 (0.51) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL1436475 | 0.89 | DPP4 (0.62) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL665960 | 0.89 | DPP4 (0.62) | DPP4DPP8DPP9DPP7PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966193-B1 | NEW SALT AND POLYMORPH OF DPP-IV INHIBITOR | HOFFMANN LA ROCHE (CH) | 2010-09-29 | — | — | EP | claimed |
| US-20100093808-A1 | SALT AND POLYMORPH OF A DPP-IV INHIBITOR | BUBENDORF ANDRE | 2010-04-15 | — | — | US | claimed |
| EP-1966193-A1 | NEW SALT AND POLYMORPH OF DPP-IV INHIBITOR | F. Hoffmann-la Roche AG (CH) | 2008-09-10 | — | — | EP | claimed |
| WO-2007071576-A1 | NEW SALT AND POLYMORPH OF DPP-IV INHIBITOR | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-28 | — | — | WO | claimed |
| US-20070142436-A1 | New salt and polymorph of a DPP-IV inhibitor | HOFFMANN-LA ROCHE INC. | 2007-06-21 | — | — | US | claimed |
| EP-1966193-B1 | NEW SALT AND POLYMORPH OF DPP-IV INHIBITOR | HOFFMANN LA ROCHE (CH) | 2010-09-29 | — | — | EP | disclosed |
| US-20100093808-A1 | SALT AND POLYMORPH OF A DPP-IV INHIBITOR | BUBENDORF ANDRE | 2010-04-15 | — | — | US | disclosed |
| US-20100093808-A1 | SALT AND POLYMORPH OF A DPP-IV INHIBITOR | BUBENDORF ANDRE | 2010-04-15 | — | — | US | disclosed |
| CN-101341148-A | New salt and polymorph of DPP-IV inhibitor | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | CN | disclosed |
| EP-1966193-A1 | NEW SALT AND POLYMORPH OF DPP-IV INHIBITOR | F. Hoffmann-la Roche AG (CH) | 2008-09-10 | — | — | EP | disclosed |
| EP-1966193-A1 | NEW SALT AND POLYMORPH OF DPP-IV INHIBITOR | F. Hoffmann-la Roche AG (CH) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071576-A1 | NEW SALT AND POLYMORPH OF DPP-IV INHIBITOR | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-28 | — | — | WO | disclosed |
| WO-2007071576-A1 | NEW SALT AND POLYMORPH OF DPP-IV INHIBITOR | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-28 | — | — | WO | disclosed |
| US-20070142436-A1 | New salt and polymorph of a DPP-IV inhibitor | HOFFMANN-LA ROCHE INC. | 2007-06-21 | — | — | US | disclosed |
| US-20070142436-A1 | New salt and polymorph of a DPP-IV inhibitor | HOFFMANN-LA ROCHE INC. | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093808-A1 | SALT AND POLYMORPH OF A DPP-IV INHIBITOR | DPP4, DPP3, DPP7 | DPP4 1/4885DPP8 4/4885DPP9 5/4885 |
| US-20070142436-A1 | New salt and polymorph of a DPP-IV inhibitor | DPP4, DPP3, DPP7 | DPP4 1/4885DPP8 4/4885DPP9 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.