Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.49 |
| ▸ | FAP | Q12884 | 1/20 | 0.46 |
| ▸ | PREP | P48147 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14634591 | 1.00 | DPP4 (0.51) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL2553750 | 0.97 | DPP4 (0.54) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL29918628 | 0.97 | DPP4 (0.54) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL195631 | 0.97 | DPP4 (0.54) | DPP4DPP8DPP9DPP7FAP | |
| Fumaric Acid SCHEMBL2932668 | 0.93 | DPP4 (0.51) | DPP4DPP8DPP9DPP7FAP | |
| Fumaric Acid SCHEMBL4968150 | 0.93 | DPP4 (0.51) | DPP4DPP8DPP9DPP7FAP | |
| Fumaric Acid SCHEMBL1038512 | 0.93 | DPP4 (0.51) | DPP4DPP8DPP9DPP7FAP | |
| Fumaric Acid SCHEMBL874060 | 0.93 | DPP4 (0.51) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL1436475 | 0.89 | DPP4 (0.62) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL665960 | 0.89 | DPP4 (0.62) | DPP4DPP8DPP9DPP7PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005929-A1 | PIPERIDINE DERIVATIVE AND ITS USE FOR THE TREATMENT OF DIABETS AND OBESITY | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |