Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8740646 | 0.98 | OPRM1 (0.40) | OPRM1OPRL1ALOX15TSHR | |
| SCHEMBL7920522 | 0.91 | ALOX15 (0.46) | OPRM1OPRL1ALOX15DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL6950425 | 0.90 | ALOX15 (0.45) | OPRM1OPRL1ALOX15TSHRDRD2 | |
| SCHEMBL14595479 | 0.88 | OPRM1 (0.43) | OPRM1OPRL1ALOX15TSHRDRD2 | |
| SCHEMBL14595476 | 0.85 | OPRM1 (0.48) | OPRM1OPRL1ALOX15DRD2DRD3 | |
| Atiprimod SCHEMBL93890 | 0.81 | OPRM1 (0.41) | OPRM1OPRL1ALOX15DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9355945 | 0.80 | ALOX15 (0.54) | OPRM1OPRL1ALOX15DRD2DRD3 | |
| SCHEMBL14595478 | 0.80 | OPRM1 (0.46) | OPRM1OPRL1ALOX15DRD2DRD3 | |
| Atiprimod SCHEMBL5116678 | 0.80 | OPRM1 (0.41) | OPRM1OPRL1ALOX15TSHRDRD2 | |
| Atiprimod SCHEMBL1650509 | 0.79 | OPRM1 (0.40) | OPRM1OPRL1ALOX15DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752856-A4 | METHODS OF TREATING HYPERLIPIDEMIA | SMITHKLINE BEECHAM CORP (US) | 1997-09-10 | — | — | EP | claimed |
| WO-1997002819-A1 | 2-[2-(DIMETHYLAMINO)ETHYL]-8,8-DIPROPYL-2-AZASPIRO[4.5]DECANE DIMALEATE | ANORMED INC, (CA) | 1997-01-30 | — | — | WO | claimed |
| EP-0752856-A1 | METHODS OF TREATING HYPERLIPIDEMIA | SMITHKLINE BEECHAM CORPORATION (US) | 1997-01-15 | — | — | EP | claimed |
| WO-1994025024-A1 | METHODS OF TREATING HYPERLIPIDEMIA | SMITHKLINE BEECHAM CORPORATION (US) | 1994-11-10 | — | — | WO | claimed |
| EP-0752856-A4 | METHODS OF TREATING HYPERLIPIDEMIA | SMITHKLINE BEECHAM CORP (US) | 1997-09-10 | — | — | EP | disclosed |
| WO-1997002819-A1 | 2-[2-(DIMETHYLAMINO)ETHYL]-8,8-DIPROPYL-2-AZASPIRO[4.5]DECANE DIMALEATE | ANORMED INC, (CA) | 1997-01-30 | — | — | WO | disclosed |
| WO-1997002819-A1 | 2-[2-(DIMETHYLAMINO)ETHYL]-8,8-DIPROPYL-2-AZASPIRO[4.5]DECANE DIMALEATE | ANORMED INC, (CA) | 1997-01-30 | — | — | WO | disclosed |
| WO-1997002819-A1 | 2-[2-(DIMETHYLAMINO)ETHYL]-8,8-DIPROPYL-2-AZASPIRO[4.5]DECANE DIMALEATE | ANORMED INC, (CA) | 1997-01-30 | — | — | WO | disclosed |
| EP-0752856-A1 | METHODS OF TREATING HYPERLIPIDEMIA | SMITHKLINE BEECHAM CORPORATION (US) | 1997-01-15 | — | — | EP | disclosed |
| WO-1994025024-A1 | METHODS OF TREATING HYPERLIPIDEMIA | SMITHKLINE BEECHAM CORPORATION (US) | 1994-11-10 | — | — | WO | disclosed |