Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Atiprimod. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Atiprimod SCHEMBL93890 | 0.97 | OPRM1 (0.41) | OPRM1OPRL1DRD2DRD3ALOX15 | |
| Atiprimod SCHEMBL5116678 | 0.96 | OPRM1 (0.41) | OPRM1OPRL1DRD2DRD3ALOX15 | |
| Atiprimod SCHEMBL8597011 | 0.87 | OPRM1 (0.38) | OPRM1OPRL1S1PR4S1PR1S1PR3 | |
| SCHEMBL7920522 | 0.85 | ALOX15 (0.46) | OPRM1OPRL1DRD2DRD3ALOX15 | |
| Hydrochloric Acid SCHEMBL6950425 | 0.83 | ALOX15 (0.45) | OPRM1OPRL1DRD2DRD3ALOX15 | |
| SCHEMBL14595479 | 0.80 | OPRM1 (0.43) | OPRM1OPRL1DRD2DRD3ALOX15 | |
| SCHEMBL14595476 | 0.79 | OPRM1 (0.48) | OPRM1OPRL1DRD2DRD3ALOX15 | |
| SCHEMBL8740612 | 0.79 | OPRM1 (0.41) | OPRM1OPRL1DRD2DRD3ALOX15 | |
| SCHEMBL8741473 | 0.79 | OPRM1 (0.41) | OPRM1OPRL1DRD2DRD3S1PR4 | |
| Hydrochloric Acid SCHEMBL8740646 | 0.77 | OPRM1 (0.40) | OPRM1OPRL1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230364074-A1 | Compounds and Compositions for Disrupting Programmed Ribosomal Frameshifting | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-11-16 | — | — | US | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230364074-A1 | Compounds and Compositions for Disrupting Programmed Ribosomal Frameshifting | SYNCRIP, FUS, SARS1 | OPRM1 2167/4885OPRL1 2841/4885DRD2 2016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.