Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8740725 | 0.79 | HPGD (0.46) | EPHX2LMNAMAPK1NLRP1HTT | |
| SCHEMBL2748481 | 0.79 | LMNA (0.52) | EPHX2LMNAMAPK1NLRP1HTT | |
| SCHEMBL18887747 | 0.75 | LMNA (0.57) | EPHX2LMNAMAPK1NLRP1HTT | |
| SCHEMBL29034668 | 0.72 | LMNA (0.57) | EPHX2LMNAMAPK1NLRP1HTT | |
| SCHEMBL2265823 | 0.72 | ALDH1A1 (0.58) | LMNAMAPK1NLRP1P2RX7ALDH1A1 | |
| SCHEMBL1143411 | 0.72 | LMNA (0.53) | LMNAMAPK1NLRP1HTTP2RX7 | |
| SCHEMBL6529545 | 0.69 | LMNA (0.60) | EPHX2LMNAMAPK1NLRP1HTT | |
| SCHEMBL23135793 | 0.69 | TDP1 (0.60) | LMNAMAPK1NLRP1HTTP2RX7 | |
| SCHEMBL14920505 | 0.68 | TSHR (0.56) | EPHX2LMNAMAPK1NLRP1P2RX7 | |
| SCHEMBL14920792 | 0.68 | LMNA (0.50) | LMNAMAPK1NLRP1P2RX7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758891-A4 | HALOMETHYL AMIDES AS IL-1-g(b) PROTEASE INHIBITORS | SANOFI WINTHROP INC (US) | 1997-12-03 | — | — | EP | claimed |
| EP-0758891-A1 | HALOMETHYL AMIDES AS IL-1$g(b) PROTEASE INHIBITORS | SANOFI WINTHROP, INC. (US) | 1997-02-26 | — | — | EP | claimed |
| WO-1995029672-A1 | HALOMETHYL AMIDES AS IL-1β PROTEASE INHIBITORS | SANOFI WINTHROP, INC. (US) | 1995-11-09 | — | — | WO | claimed |