SCHEMBL8740861

SCHEMBL8740861

Cc1nnc(S)n1-c1cccc(S(=O)(=O)O)c1.[NaH]

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.38
TSHR P16473 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
HSD17B10 Q99714 1/20 0.38
NR1H2 P55055 3/20 0.34
NR1H3 Q13133 3/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C19 P33261 1/20 0.34
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
CA9 Q16790 2/20 0.34
CA12 O43570 1/20 0.34
KDM4E B2RXH2 3/20 0.34
HTT P42858 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
XBP1 P17861 1/20 0.33
HSP90AA1 P07900 1/20 0.33
HSP90AB1 P08238 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8740860 0.83 LMNA (0.39) TDP1NR1H2NR1H3CYP2D6CYP2C19
SCHEMBL14112936 0.76 TDP1 (0.49) ALDH1A1TDP1KDM4ELMNAMAPT
SCHEMBL8740825 0.73 TSHR (0.39) ALDH1A1TSHRTDP1HSD17B10KDM4E
SCHEMBL1156164 0.73 LMNA (0.43) ALDH1A1TSHRTDP1HSD17B10CA1
SCHEMBL13401048 0.73 NOTUM (0.43) ALDH1A1HSD17B10CYP2D6CYP2C19KDM4E
SCHEMBL278418 0.71 LMNA (0.43) ALDH1A1TSHRTDP1HSD17B10CA1
SCHEMBL31457351 0.71 LMNA (0.43) ALDH1A1TSHRTDP1HSD17B10CA1
SCHEMBL4591741 0.71 LMNA (0.43) ALDH1A1TSHRTDP1HSD17B10CA1
SCHEMBL29672419 0.71 LMNA (0.43) ALDH1A1TSHRTDP1HSD17B10CA1
SCHEMBL13135715 0.71 TSHR (0.40) ALDH1A1TSHRTDP1HSD17B10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5667936-A FLUOROMETHYLATED HYDRAZIDE, HIGH CONTRAST, PROCESSING STABILITY, PRESERVABILITY FUJI PHOTO FILM CO., LTD. (JP) 1997-09-16 US disclosed
EP-0736798-A1 Silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1996-10-09 EP disclosed