SCHEMBL8740993

SCHEMBL8740993

COC1CN(c2c(F)cc3c(=O)c(C(=O)OC(=O)C(F)(F)F)cn(C4CC4)c3c2Cl)CC1N

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.56
POLB P06746 2/20 0.56
OPRM1 P35372 2/20 0.56
CHRM2 P08172 1/20 0.56
CHRM1 P11229 1/20 0.56
OPRD1 P41143 1/20 0.56
KCNH2 Q12809 5/20 0.43
KDM4E B2RXH2 3/20 0.42
HPGD P15428 3/20 0.42
HSD17B10 Q99714 2/20 0.42
PRKD3 O94806 1/20 0.42
ALOX15 P16050 1/20 0.42
CLK2 P49760 1/20 0.42
CLK4 Q9HAZ1 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL8740995 0.89 ALDH1A1 (0.65) ALDH1A1POLBOPRM1CHRM2CHRM1
Trifluoroacetic Acid SCHEMBL8740990 0.89 ALDH1A1 (0.65) ALDH1A1POLBOPRM1CHRM2CHRM1
Trifluoroacetic Acid SCHEMBL6213055 0.84 ALDH1A1 (0.52) ALDH1A1POLBOPRM1CHRM2CHRM1
SCHEMBL8929962 0.80 ALDH1A1 (0.53) ALDH1A1POLBOPRM1CHRM2CHRM1
Trifluoroacetic Acid SCHEMBL8741059 0.80 ADRB2 (0.51) ALDH1A1POLBOPRM1CHRM2CHRM1
Trifluoroacetic Acid SCHEMBL8741058 0.80 ADRB2 (0.51) ALDH1A1POLBOPRM1CHRM2CHRM1
SCHEMBL9268812 0.80 ALDH1A1 (0.58) ALDH1A1POLBOPRM1CHRM2CHRM1
Hydrochloric Acid SCHEMBL8741009 0.79 ALDH1A1 (0.57) ALDH1A1POLBOPRM1CHRM2CHRM1
Hydrochloric Acid SCHEMBL8741309 0.79 ALDH1A1 (0.57) ALDH1A1POLBOPRM1CHRM2CHRM1
Hydrochloric Acid SCHEMBL8741291 0.79 ALDH1A1 (0.57) ALDH1A1POLBOPRM1CHRM2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5607942-A BACTERICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-03-04 US disclosed
US-5416096-A 7-(1-pyrrolidinyl)-3-quinolone carboxylic acid derivatives as antibacterial agents and feed additives BAYER AKTIENGESELLSCHAFT (DE) 1995-05-16 US disclosed
US-5059597-A Animal growth regulators; enterobacter BAYER AKTIENGESELLSCHAFT (DE) 1991-10-22 US disclosed
US-4990517-A 7-(1-pyrrolidinyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives as antibacterial agents and feed additives BAYER AKTIENGESELLSCHAFT (DE) 1991-02-05 US disclosed