Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.72 |
| ▸ | HPGD | P15428 | 8/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | CA12 | O43570 | 1/20 | 0.72 |
| ▸ | CA1 | P00915 | 1/20 | 0.72 |
| ▸ | CA2 | P00918 | 1/20 | 0.72 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.72 |
| ▸ | CA4 | P22748 | 1/20 | 0.72 |
| ▸ | CA6 | P23280 | 1/20 | 0.72 |
| ▸ | CA7 | P43166 | 1/20 | 0.72 |
| ▸ | CA9 | Q16790 | 1/20 | 0.72 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.72 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | G6PD | P11413 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL31251472 | 1.00 | ALDH1A1 (0.72) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL515324 | 0.98 | ALDH1A1 (0.69) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL515322 | 0.98 | ALDH1A1 (0.69) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL15568422 | 0.92 | ALDH1A1 (0.78) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL27871001 | 0.92 | ALDH1A1 (0.78) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL27657568 | 0.91 | KDM4E (0.60) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL27880804 | 0.90 | ALDH1A1 (0.75) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1835793 | 0.88 | ALDH1A1 (0.72) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Phthalic Acid SCHEMBL28654022 | 0.87 | ALDH1A1 (0.67) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL28611199 | 0.86 | ALDH1A1 (0.69) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3863618-A1 | METHODS OF TREATING CANCER WITH PI3K ALPHA INHIBITORS AND METFORMIN | F. Hoffmann-La Roche AG (CH) | 2021-08-18 | — | — | EP | disclosed |
| CN-109627500-A | A kind of anti-oxidant antibacterial fully bio-degradable novel foodstuff packaging film based on organic acid | 王浚杰 | 2019-04-16 | — | — | CN | disclosed |
| EP-0756479-A4 | GENTLE ANTI-ACNE COMPOSITION | AVON PROD INC (US) | 1997-05-07 | — | — | EP | disclosed |
| CN-1148334-A | Mild anti-acne compositions | AVON PROD INC (US) | 1997-04-23 | — | — | CN | disclosed |
| EP-0756479-A1 | GENTLE ANTI-ACNE COMPOSITION | AVON PRODUCTS, INC. (US) | 1997-02-05 | — | — | EP | disclosed |
| US-5569651-A | TOPICAL FORMULATION CONTAINING SALICYLIC AND LACTIC ACIDS ADJUSTED TO SELECTED PH AND PLACED IN SUITABLE VEHICLE | AVON PRODUCTS, INC. (US) | 1996-10-29 | — | — | US | disclosed |
| WO-1996027365-A1 | GENTLE ANTI-ACNE COMPOSITION | AVON PRODUCTS, INC. (US) | 1996-09-12 | — | — | WO | disclosed |