Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.69 |
| ▸ | HPGD | P15428 | 8/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | CA12 | O43570 | 1/20 | 0.69 |
| ▸ | CA1 | P00915 | 1/20 | 0.69 |
| ▸ | CA2 | P00918 | 1/20 | 0.69 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.69 |
| ▸ | CA4 | P22748 | 1/20 | 0.69 |
| ▸ | CA6 | P23280 | 1/20 | 0.69 |
| ▸ | CA7 | P43166 | 1/20 | 0.69 |
| ▸ | CA9 | Q16790 | 1/20 | 0.69 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.69 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | G6PD | P11413 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL515324 | 1.00 | ALDH1A1 (0.69) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL8742102 | 0.98 | ALDH1A1 (0.72) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL31251472 | 0.98 | ALDH1A1 (0.72) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL27871001 | 0.90 | ALDH1A1 (0.78) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL15568422 | 0.90 | ALDH1A1 (0.78) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL27657568 | 0.90 | KDM4E (0.60) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL27880804 | 0.88 | ALDH1A1 (0.75) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1835793 | 0.86 | ALDH1A1 (0.72) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Phthalic Acid SCHEMBL28654022 | 0.86 | ALDH1A1 (0.67) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1062720 | 0.85 | ALDH1A1 (0.95) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498746-B1 | SKIN CARE COMPOSITIONS COMPRISING PHENOXYALKYL AMINES | UNILEVER PLC NO 41424 (GB) | 2016-08-24 | — | — | EP | disclosed |
| EP-2598110-B1 | SKIN CARE COMPOSITIONS COMPRISING SUBSTITUTED MONOAMINES | UNILEVER PLC (GB) | 2015-09-02 | — | — | EP | disclosed |
| EP-2598111-B1 | SKIN CARE COMPOSITIONS COMPRISING SUBSTITUTED DIAMINES | UNILEVER PLC (GB) | 2015-03-25 | — | — | EP | disclosed |
| US-8476251-B2 | Skin care compositions comprising substituted diamines | CONOPCO, INC. (US) | 2013-07-02 | — | — | US | disclosed |
| EP-2598110-A2 | SKIN CARE COMPOSITIONS COMPRISING SUBSTITUTED MONOAMINES | Unilever PLC (GB) | 2013-06-05 | — | — | EP | disclosed |
| EP-2598111-A2 | SKIN CARE COMPOSITIONS COMPRISING SUBSTITUTED DIAMINES | Unilever PLC (GB) | 2013-06-05 | — | — | EP | disclosed |
| US-8309064-B2 | Skin care compositions comprising phenoxyalkyl amines | CONOPCO, INC. (US) | 2012-11-13 | — | — | US | disclosed |
| US-8293218-B2 | Skin care compositions comprising substituted monoamines | CONOPCO, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| EP-2498746-A2 | SKIN CARE COMPOSITIONS COMPRISING PHENOXYALKYL AMINES | Unilever Plc, A Company Registered In England And Wales under company no. 41424 of Unilever House (GB) | 2012-09-19 | — | — | EP | disclosed |
| US-20120027699-A1 | SKIN CARE COMPOSITIONS COMPRISING SUBSTITUTED MONOAMINES | CONOPCO, INC., D/B/A UNILEVER (US) | 2012-02-02 | — | — | US | disclosed |
| US-20120027700-A1 | SKIN CARE COMPOSITIONS COMPRISING SUBSTITUTED DIAMINES | CONOPCO, INC., D/B/A UNILEVER (US) | 2012-02-02 | — | — | US | disclosed |
| WO-2012013417-A2 | SKIN CARE COMPOSITIONS COMPRISING SUBSTITUTED DIAMINES | UNILEVER PLC (GB) | 2012-02-02 | — | — | WO | disclosed |
| WO-2012013418-A2 | SKIN CARE COMPOSITIONS COMPRISING SUBSTITUTED MONOAMINES | UNILEVER PLC (GB) | 2012-02-02 | — | — | WO | disclosed |
| WO-2011054804-A2 | SKIN CARE COMPOSITIONS COMPRISING PHENOXYALKYL AMINES | UNILEVER PLC (GB) | 2011-05-12 | — | — | WO | disclosed |
| US-20110110870-A1 | SKIN CARE COMPOSITIONS COMPRISING PHENOXYALKYL AMINES | CONOPCO, INC., D/B/A UNILEVER (US) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120027699-A1 | SKIN CARE COMPOSITIONS COMPRISING SUBSTITUTED MONOAMINES | TYR, CUTA, MAOA | ALDH1A1 606/4885HPGD 2211/4885KDM4E 331/4885 |
| US-20110110870-A1 | SKIN CARE COMPOSITIONS COMPRISING PHENOXYALKYL AMINES | CUTA, TYR, FLNA | ALDH1A1 1317/4885HPGD 2000/4885KDM4E 89/4885 |
| US-20120027700-A1 | SKIN CARE COMPOSITIONS COMPRISING SUBSTITUTED DIAMINES | CUTA, TYR, DSG1 | ALDH1A1 885/4885HPGD 1505/4885KDM4E 658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.