Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.35 |
| ▸ | HTR3B | O95264 | 2/20 | 0.35 |
| ▸ | HTR3A | P46098 | 2/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | F10 | P00742 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11877504 | 0.80 | LMNA (0.37) | HSD17B10CYP3A4MAPK1LMNAKDR | |
| SCHEMBL5519442 | 0.77 | NPC1 (0.43) | HPGDHSD17B10TSHRCASP1CYP3A4 | |
| SCHEMBL11883751 | 0.77 | HTR3E (0.40) | HPGDHSD17B10TSHRCASP1CYP3A4 | |
| SCHEMBL5520771 | 0.77 | KMT2A (0.39) | HPGDHSD17B10TSHRCASP1CYP3A4 | |
| SCHEMBL11883596 | 0.77 | ALDH1A1 (0.39) | HPGDHSD17B10TSHRCASP1CYP3A4 | |
| SCHEMBL11880741 | 0.74 | GAA (0.32) | — | |
| SCHEMBL8742365 | 0.74 | CYP3A4 (0.40) | HPGDHSD17B10TSHRCASP1CYP3A4 | |
| SCHEMBL11879848 | 0.74 | PLAU (0.34) | MAPK1ALDH1A1 | |
| SCHEMBL11883024 | 0.74 | CYP1A2 (0.35) | LMNACYP1A2ADRA2AADRA2CBLM | |
| SCHEMBL11881186 | 0.74 | HTT (0.43) | HPGDTSHRF2F10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0746316-A4 | THERAPEUTIC GUANIDINES | CAMBRIDGE NEUROSCIENCE INC (US) | 1997-12-10 | — | — | EP | claimed |
| EP-0746316-A1 | THERAPEUTIC GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1996-12-11 | — | — | EP | claimed |
| WO-1995014467-A1 | THERAPEUTIC GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1995-06-01 | — | — | WO | claimed |