Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | LTA4H | P09960 | 1/20 | 0.59 |
| ▸ | ACACB | O00763 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31427171 | 0.88 | LTA4H (0.64) | ALDH1A1KDM4EGAASMN1; SMN2LTA4H | |
| SCHEMBL874127 | 0.88 | LTA4H (0.63) | KDM4ELTA4HKMT2AMEN1HRH3 | |
| SCHEMBL10897064 | 0.87 | ALDH1A1 (0.67) | ALDH1A1KDM4EGAASMN1; SMN2LTA4H | |
| SCHEMBL15392094 | 0.82 | LTA4H (0.66) | ALDH1A1KDM4EGAASMN1; SMN2LTA4H | |
| SCHEMBL10898384 | 0.82 | ALDH1A1 (0.68) | ALDH1A1KDM4EGAASMN1; SMN2LTA4H | |
| SCHEMBL6689250 | 0.81 | ALDH1A1 (0.70) | ALDH1A1KDM4EGAASMN1; SMN2LTA4H | |
| SCHEMBL4455251 | 0.81 | ALDH1A1 (0.92) | ALDH1A1KDM4EGAASMN1; SMN2KMT2A | |
| SCHEMBL5306939 | 0.81 | HDAC1 (0.57) | ALDH1A1KDM4EGAASMN1; SMN2LTA4H | |
| SCHEMBL10377 | 0.81 | NPC1 (0.58) | ALDH1A1KDM4EGAASMN1; SMN2LTA4H | |
| SCHEMBL492219 | 0.81 | HRH3 (0.75) | KDM4EKMT2AMAPTMEN1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619184-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of the University of Michigan (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040527-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | WO | disclosed |