Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HRH2 | P25021 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10626 | 0.95 | HRH3 (0.63) | HRH3ALDH1A1HRH2HRH1LMNA | |
| SCHEMBL5306939 | 0.84 | HDAC1 (0.57) | LTA4HGAASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL10637 | 0.83 | HRH3 (0.76) | HRH3HRH1 | |
| SCHEMBL1395845 | 0.83 | LTA4H (0.61) | NPC1RAB9ALTA4HGAASMN1; SMN2 | |
| SCHEMBL31427171 | 0.82 | LTA4H (0.64) | NPC1RAB9ALTA4HGAASMN1; SMN2 | |
| SCHEMBL874263 | 0.81 | ALDH1A1 (0.64) | NPC1RAB9AHRH3LTA4HGAA | |
| SCHEMBL28502559 | 0.81 | NPC1 (0.67) | NPC1RAB9AHRH3LTA4HGAA | |
| SCHEMBL874183 | 0.80 | LTA4H (0.61) | NPC1RAB9AHRH3LTA4HCA12 | |
| SCHEMBL10132861 | 0.80 | NPC1 (0.63) | NPC1RAB9AHRH3LTA4HGAA | |
| SCHEMBL873542 | 0.79 | ALDH1A1 (0.74) | NPC1RAB9AHRH3LTA4HGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488489-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | Pfizer Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045703-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2011-04-21 | — | — | WO | disclosed |