Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.59 |
| ▸ | RECQL | P46063 | 3/20 | 0.59 |
| ▸ | BLM | P54132 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873592 | 0.87 | EGFR (0.59) | EGFRALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL1934787 | 0.87 | USP9X (0.68) | EGFRALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL874086 | 0.81 | ALDH1A1 (0.41) | EGFRALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL874550 | 0.81 | KMT2A (0.45) | EGFRALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL7374065 | 0.81 | EGFR (0.77) | EGFRALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL7372771 | 0.80 | EGFR (0.72) | EGFRALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL874963 | 0.79 | USP9X (0.62) | EGFRALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL1934987 | 0.79 | USP9X (0.72) | EGFRALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL1934789 | 0.79 | ALDH1A1 (0.56) | EGFRALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL874244 | 0.79 | KMT2A (0.54) | ALDH1A1MAPTKDM4EMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619184-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of the University of Michigan (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040527-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | WO | disclosed |