Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | USP9X | Q93008 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | USP24 | Q9UPU5 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874550 | 0.93 | KMT2A (0.45) | KMT2AGAAUSP9XMAPK1ALDH1A1 | |
| SCHEMBL874086 | 0.81 | ALDH1A1 (0.41) | KMT2AGAAUSP9XMAPK1LMNA | |
| SCHEMBL23171347 | 0.81 | USP9X (0.61) | KMT2AGAAUSP9XLMNACACNA1B | |
| SCHEMBL863520 | 0.79 | USP9X (0.78) | KMT2AGAAUSP9XCACNA1BAPBA1 | |
| SCHEMBL863519 | 0.79 | USP9X (0.78) | KMT2AGAAUSP9XCACNA1BAPBA1 | |
| SCHEMBL874284 | 0.79 | EGFR (0.59) | KMT2AGAAUSP9XMAPK1LMNA | |
| SCHEMBL873719 | 0.75 | POLB (0.50) | KMT2AGAAMAPK1ALDH1A1KDM4E | |
| SCHEMBL873696 | 0.73 | USP9X (0.52) | KMT2AGAAUSP9XMAPK1LMNA | |
| SCHEMBL874558 | 0.72 | USP9X (0.51) | KMT2AGAAUSP9XMAPK1LMNA | |
| SCHEMBL864702 | 0.72 | USP9X (0.68) | KMT2AGAAUSP9XALDH1A1USP24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619184-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of the University of Michigan (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040527-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | WO | disclosed |