SCHEMBL8743296

SCHEMBL8743296

c1ccc(NN=Nc2nccs2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 4/20 0.48
CYP1A1 P04798 1/20 0.48
TSHR P16473 1/20 0.48
CYP1B1 Q16678 1/20 0.48
KMT2A Q03164 9/20 0.42
MEN1 O00255 7/20 0.42
MAPT P10636 7/20 0.42
RAB9A P51151 6/20 0.42
MAPK1 P28482 4/20 0.42
L3MBTL1 Q9Y468 4/20 0.42
NPSR1 Q6W5P4 3/20 0.42
KDM4E B2RXH2 3/20 0.42
POLB P06746 2/20 0.42
HSP90AA1 P07900 2/20 0.42
PAX8 Q06710 1/20 0.42
KCNH2 Q12809 1/20 0.42
RIOK2 Q9BVS4 1/20 0.42
NPC1 O15118 4/20 0.42
CASP3 P42574 2/20 0.42
SENP8 Q96LD8 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10827438 0.82 KMT2A (0.42) TDP1CYP1A1TSHRCYP1B1KMT2A
SCHEMBL8518945 0.75 MAPT (0.52) TDP1TSHRKMT2AMEN1MAPT
SCHEMBL8518947 0.75 MAPT (0.52) TDP1TSHRKMT2AMEN1MAPT
SCHEMBL1305759 0.74 KMT2A (0.50) TDP1KMT2AMEN1MAPTRAB9A
SCHEMBL1305761 0.74 KMT2A (0.50) TDP1KMT2AMEN1MAPTRAB9A
SCHEMBL2199674 0.72 MAPT (0.55) TDP1TSHRKMT2AMEN1MAPT
SCHEMBL8743302 0.70 AURKA (0.39) TDP1CYP1A1TSHRCYP1B1KMT2A
SCHEMBL8986676 0.69 CYP1A1 (0.53) TDP1CYP1A1TSHRCYP1B1KMT2A
SCHEMBL8746725 0.69 TDP1 (0.48) TDP1CYP1A1TSHRCYP1B1KMT2A
SCHEMBL9134608 0.69 TDP1 (0.48) TDP1CYP1A1TSHRCYP1B1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5616697-A THIAZOLYL RING CONTAINS A SUBSTITUENT SELECTED FORM HYDROXY, ALKOXY, CYCLOALKOXY, ARYLOXY, MERCAPTO, THIOALKYL, THIOCYCLOALKYL AND THIOARYL AT 4-POSITION AGFA-GEVAERT, N.V. (BE) 1997-04-01 US claimed
EP-0581342-B1 Dye-donor element for use according to thermal dye sublimation transfer AGFA GEVAERT NV (BE) 1997-01-02 EP claimed
EP-0579299-B1 Black colored dye mixture for use according to thermal dye sublimation transfer AGFA GEVAERT NV (BE) 1997-01-02 EP claimed
EP-0578870-B1 Thiazolylazoaniline dyes for use in thermal dye sublimation transfer AGFA GEVAERT NV (BE) 1996-12-11 EP claimed
US-5476746-A For recording hard copies of medical diagnostic images that behave visually as metallic silver AGFA-GEVAERT, N.V. (BE) 1995-12-19 US claimed
US-5432040-A Colorfast AGFA-GEVAERT, N.V. (BE) 1995-07-11 US claimed
US-5366951-A Support with dye donor elements or dye receiver elements AGFA-GEVAERT, N.V. (BE) 1994-11-22 US claimed
EP-0581342-A1 Dye-donor element for use according to thermal dye sublimation transfer AGFA-GEVAERT N.V. (BE) 1994-02-02 EP claimed
EP-0578870-A1 Thiazolylazoaniline dyes for use in thermal dye sublimation transfer AGFA-GEVAERT N.V. (BE) 1994-01-19 EP claimed
EP-0579299-A1 Black colored dye mixture for use according to thermal dye sublimation transfer AGFA-GEVAERT N.V. (BE) 1994-01-19 EP claimed
JP-6072056-A None JP disclosed
JP-6092045-A None JP disclosed
US-5616697-A THIAZOLYL RING CONTAINS A SUBSTITUENT SELECTED FORM HYDROXY, ALKOXY, CYCLOALKOXY, ARYLOXY, MERCAPTO, THIOALKYL, THIOCYCLOALKYL AND THIOARYL AT 4-POSITION AGFA-GEVAERT, N.V. (BE) 1997-04-01 US disclosed
US-5616697-A THIAZOLYL RING CONTAINS A SUBSTITUENT SELECTED FORM HYDROXY, ALKOXY, CYCLOALKOXY, ARYLOXY, MERCAPTO, THIOALKYL, THIOCYCLOALKYL AND THIOARYL AT 4-POSITION AGFA-GEVAERT, N.V. (BE) 1997-04-01 US disclosed
US-5616697-A THIAZOLYL RING CONTAINS A SUBSTITUENT SELECTED FORM HYDROXY, ALKOXY, CYCLOALKOXY, ARYLOXY, MERCAPTO, THIOALKYL, THIOCYCLOALKYL AND THIOARYL AT 4-POSITION AGFA-GEVAERT, N.V. (BE) 1997-04-01 US disclosed
EP-0581342-A1 Dye-donor element for use according to thermal dye sublimation transfer AGFA-GEVAERT N.V. (BE) 1994-02-02 EP disclosed
EP-0578870-A1 Thiazolylazoaniline dyes for use in thermal dye sublimation transfer AGFA-GEVAERT N.V. (BE) 1994-01-19 EP disclosed
EP-0578870-A1 Thiazolylazoaniline dyes for use in thermal dye sublimation transfer AGFA-GEVAERT N.V. (BE) 1994-01-19 EP disclosed
EP-0578870-A1 Thiazolylazoaniline dyes for use in thermal dye sublimation transfer AGFA-GEVAERT N.V. (BE) 1994-01-19 EP disclosed
EP-0579299-A1 Black colored dye mixture for use according to thermal dye sublimation transfer AGFA-GEVAERT N.V. (BE) 1994-01-19 EP disclosed