Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 8/20 | 0.51 |
| ▸ | HPRT1 | P00492 | 7/20 | 0.50 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | HBB | P68871 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8743558 | 0.86 | PNP (0.50) | PNPHPRT1XDHBLMHBB | |
| SCHEMBL8743547 | 0.82 | BLM (0.56) | PNPHPRT1BLMHBBUSP2 | |
| SCHEMBL8743559 | 0.82 | HDAC1 (0.36) | HPRT1ALDH1A1CYP3A4HIF1A | |
| SCHEMBL9747416 | 0.79 | HPRT1 (0.45) | PNPHPRT1XDHMEN1KMT2A | |
| SCHEMBL10598150 | 0.78 | HPRT1 (0.44) | PNPHPRT1XDHBLMHBB | |
| SCHEMBL7669042 | 0.75 | HPRT1 (0.49) | PNPHPRT1XDHBLMHBB | |
| SCHEMBL9187381 | 0.75 | PNP (0.56) | PNPHPRT1XDHBLMHBB | |
| SCHEMBL8743551 | 0.74 | HPRT1 (0.39) | PNPHPRT1XDHALDH1A1LMNA | |
| SCHEMBL9740943 | 0.74 | PNP (0.67) | PNPHPRT1BLMHBBUSP2 | |
| SCHEMBL8990380 | 0.74 | HPRT1 (0.57) | PNPHPRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0335770-B1 | Novel fluorophosphonate nucleotide derivatives | MERRELL PHARMA INC (US) | 1997-01-15 | — | — | EP | disclosed |
| EP-0339161-A1 | Novel fluorophosphonate nucleotide derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-11-02 | — | — | EP | disclosed |
| EP-0335770-A2 | Novel fluorophosphonate nucleotide derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1989-10-04 | — | — | EP | disclosed |