Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | TPO | P07202 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8743535 | 0.90 | KDM4E (0.35) | MAOAMAOBMPOTPOCYP3A4 | |
| SCHEMBL8743582 | 0.83 | MAOA (0.37) | MAOAMAOBMPOTPOCYP3A4 | |
| SCHEMBL8743542 | 0.81 | MAPT (0.36) | MAOAMAOBALDH1A1MAPK1TSHR | |
| SCHEMBL9652268 | 0.81 | MAPK1 (0.38) | MAOAMAOBMPOTPOCYP3A4 | |
| SCHEMBL8743556 | 0.81 | FGFR1 (0.39) | FGFR1SLC22A6 | |
| SCHEMBL8743537 | 0.79 | MAOB (0.34) | MAOAMAOBNR4A2MAPK1PDE2A | |
| SCHEMBL8743558 | 0.74 | PNP (0.50) | CYP3A4ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL8743583 | 0.74 | HDAC6 (0.38) | MAOAMAOBCYP3A4ALDH1A1PDE2A | |
| SCHEMBL8743561 | 0.73 | MAPT (0.35) | MAOAMAOBALDH1A1MAPK1TSHR | |
| SCHEMBL8743549 | 0.72 | MAOA (0.35) | MAOAMAOBMPOTPOCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0335770-B1 | Novel fluorophosphonate nucleotide derivatives | MERRELL PHARMA INC (US) | 1997-01-15 | — | — | EP | disclosed |
| EP-0339161-A1 | Novel fluorophosphonate nucleotide derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-11-02 | — | — | EP | disclosed |
| EP-0335770-A2 | Novel fluorophosphonate nucleotide derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1989-10-04 | — | — | EP | disclosed |