SCHEMBL8743585

SCHEMBL8743585

Nc1nc(Cl)c2ncn(CC(F)(F)CC(O)OCc3ccccc3)c2n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 11/20 0.43
HDAC1 Q13547 9/20 0.43
HDAC2 Q92769 3/20 0.43
HDAC4 P56524 5/20 0.42
PDE4A P27815 1/20 0.41
PDE4B Q07343 1/20 0.41
PDE4C Q08493 1/20 0.41
PDE4D Q08499 1/20 0.41
HSP90AA1 P07900 4/20 0.40
HSP90AB1 P08238 4/20 0.40
ALDH1A1 P00352 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
HIF1A Q16665 1/20 0.40
PHLPP2 Q6ZVD8 1/20 0.40
HDAC3 O15379 2/20 0.40
HDAC7 Q8WUI4 2/20 0.40
HDAC10 Q969S8 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8743563 0.78 HDAC6 (0.44) HDAC6HDAC1HDAC2HDAC4HSP90AA1
SCHEMBL6272417 0.74 ALDH1A1 (0.66) HDAC6HDAC1HDAC2HDAC4PDE4A
SCHEMBL14477480 0.73 HDAC6 (0.51) HDAC6HDAC1HDAC2HDAC4HSP90AA1
SCHEMBL10996722 0.72 HDAC1 (0.47) HDAC6HDAC1HDAC2HDAC4HSP90AA1
SCHEMBL10508890 0.71 HDAC1 (0.46) HDAC6HDAC1HDAC2HDAC4HSP90AA1
SCHEMBL10510295 0.71 HDAC1 (0.44) HDAC6HDAC1HDAC2HDAC4HSP90AA1
SCHEMBL8904140 0.70 HDAC1 (0.45) HDAC6HDAC1HDAC2HDAC4HSP90AA1
SCHEMBL8743523 0.70 HDAC6 (0.46) HDAC6HDAC1HDAC2HDAC4HSP90AA1
SCHEMBL1663801 0.70 HDAC1 (0.43) HDAC6HDAC1HDAC2HDAC4HSP90AA1
SCHEMBL1663924 0.70 HDAC1 (0.43) HDAC6HDAC1HDAC2HDAC4HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0335770-B1 Novel fluorophosphonate nucleotide derivatives MERRELL PHARMA INC (US) 1997-01-15 EP disclosed
EP-0339161-A1 Novel fluorophosphonate nucleotide derivatives MERRELL DOW PHARMACEUTICALS INC. (US) 1989-11-02 EP disclosed
EP-0335770-A2 Novel fluorophosphonate nucleotide derivatives MERRELL PHARMACEUTICALS INC. (US) 1989-10-04 EP disclosed