Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3626577 | 0.81 | ALDH1A1 (0.42) | ALDH1A1HPGDLMNACES1TDP1 | |
| SCHEMBL11884763 | 0.75 | ALDH1A1 (0.40) | AKT1ALDH1A1HPGDLMNACES1 | |
| SCHEMBL11884753 | 0.75 | ALDH1A1 (0.40) | AKT1ALDH1A1HPGDLMNACES1 | |
| SCHEMBL27722919 | 0.74 | RECQL (0.46) | AKT1ALDH1A1HPGDLMNACES1 | |
| SCHEMBL6393324 | 0.73 | LMNA (0.49) | AKT1ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL6393316 | 0.73 | AKT1 (0.41) | AKT1ALDH1A1HPGDLMNACES1 | |
| SCHEMBL6157296 | 0.73 | LMNA (0.44) | AKT1ALDH1A1HPGDLMNAMAPK1 | |
| SCHEMBL5610425 | 0.72 | TSHR (0.50) | HPGDCES1MAPK1TDP1KDM4E | |
| SCHEMBL11884770 | 0.72 | ALDH1A1 (0.37) | ALDH1A1LMNAMAPTMEN1CYP3A4 | |
| SCHEMBL1782352 | 0.72 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPK1TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0246534-B1 | Optically pure 4,5-disubstituted gamma-butyrolactame enantiomers, process for their preparation and their use | BAYER AG (DE) | 1997-01-15 | — | — | EP | claimed |
| EP-0246534-B1 | Optically pure 4,5-disubstituted gamma-butyrolactame enantiomers, process for their preparation and their use | BAYER AG (DE) | 1997-01-15 | — | — | EP | disclosed |
| EP-0246534-A2 | Optically pure 4,5-disubstituted gamma-butyrolactame enantiomers, process for their preparation and their use | BAYER AG (DE) | 1987-11-25 | — | — | EP | disclosed |