SCHEMBL8744072

SCHEMBL8744072

FC1CCC(=Nc2ccc(Oc3ccccc3)cc2)CC1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 8/20 0.39
TSHR P16473 1/20 0.39
HRH3 Q9Y5N1 1/20 0.38
KDM1A O60341 1/20 0.37
NR1H2 P55055 1/20 0.36
BAX Q07812 1/20 0.36
MAOA P21397 1/20 0.36
SOS1 Q07889 1/20 0.35
NOS3 P29474 2/20 0.34
NOS1 P29475 2/20 0.34
NOS2 P35228 2/20 0.34
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
MAPT P10636 1/20 0.33
ALOX12 P18054 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8744151 0.84 ALDH1A1 (0.33)
SCHEMBL8743981 0.84 LTA4H (0.40) LTA4HTSHRHRH3KDM1ANR1H2
SCHEMBL8743927 0.84 NPC1 (0.46) LTA4HTSHRHRH3KDM1ANR1H2
SCHEMBL8743918 0.81 LTA4H (0.42) LTA4HTSHRHRH3KDM1ANR1H2
SCHEMBL8743965 0.80 LTA4H (0.41) LTA4HTSHRHRH3KDM1ANOS3
SCHEMBL8744014 0.80 PTGS2 (0.39) TSHRMAOANOS3CA1CA2
SCHEMBL8744041 0.80 LTA4H (0.44) LTA4HTSHRHRH3KDM1ANR1H2
SCHEMBL8743913 0.74 HPGD (0.34) NPC1RAB9AMAPTALOX12SMN1; SMN2
SCHEMBL8743974 0.73 POLB (0.45) LTA4HHRH3MAOARAB9AMAPT
SCHEMBL8743970 0.73 POLB (0.45) LTA4HHRH3MAOARAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5618980-A DEHYDROGENATING N-CYCLOHEXYLIDENEAMINO COMPOUND IN PRESENCE OF HYDROGEN TRANSFER CATALYST AND HYDROGEN ACCEPTOR AND ALKALI OR ALKALINE EARTH METAL COMPOUND COCATALYST MITSUI TOATSU CHEMICALS, INC. (JP) 1997-04-08 US disclosed
EP-0588060-B1 Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS (JP) 1997-04-02 EP disclosed
EP-0753505-A2 Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS, Inc. (JP) 1997-01-15 EP disclosed
US-5536878-A HYDROGEN ACCEPTOR MITSUI TOATSU CHEMICALS, INC. (JP) 1996-07-16 US disclosed
US-5382690-A Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1995-01-17 US disclosed
EP-0588060-A2 Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS, Inc. (JP) 1994-03-23 EP disclosed