Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708189 | 0.89 | CES2 (0.33) | CES2LMNACES1HIF1AEPAS1 | |
| SCHEMBL22206336 | 0.89 | CES2 (0.33) | CES2LMNACES1HIF1AEPAS1 | |
| SCHEMBL28975466 | 0.74 | CES2 (0.34) | CES2LMNACES1HIF1AEPAS1 | |
| SCHEMBL5492719 | 0.74 | ALDH1A1 (0.34) | CES2LMNACES1HIF1AEPAS1 | |
| SCHEMBL10399319 | 0.69 | CES2 (0.36) | CES2LMNACES1HIF1AEPAS1 | |
| SCHEMBL8822163 | 0.68 | CES2 (0.33) | CES2LMNACES1HIF1AEPAS1 | |
| SCHEMBL27818420 | 0.68 | CES2 (0.33) | CES2LMNACES1HIF1AEPAS1 | |
| SCHEMBL27818419 | 0.68 | CES2 (0.33) | CES2LMNACES1HIF1AEPAS1 | |
| SCHEMBL9064468 | 0.67 | CES2 (0.34) | CES2LMNACES1TDP1L3MBTL1 | |
| SCHEMBL28597160 | 0.67 | CES2 (0.34) | CES2LMNACES1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661136-A | 2-halo-2'-fluoro ARA adenosines as antinoplastic agents | SOUTHERN RESEARCH INSTITUTE (US) | 1997-08-26 | — | — | US | disclosed |
| EP-0473708-B1 | 2-HALO-9-(2-DEOXY-2-FLUORO-B-D-ARABINOFURANOSYL) ADENINE NUCLEOSIDE DERIVATIVES | SOUTHERN RES INST (US) | 1997-01-15 | — | — | EP | disclosed |
| EP-0595826-A4 | 2'-FLUORO-2-SUBSTITUTED ADENINYL ARABINOSIDES AS ANTI-CANCER AGENTS | SOUTHERN RES INST (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5384310-A | Antitumor | SOUTHERN RESEARCH INSTITUTE (US) | 1995-01-24 | — | — | US | disclosed |
| EP-0595826-A1 | 2'-FLUORO-2-SUBSTITUTED ADENINYL ARABINOSIDES AS ANTI-CANCER AGENTS | Southern Research Institute (US) | 1994-05-11 | — | — | EP | disclosed |
| WO-1992020347-A1 | 2'-FLUORO-2-SUBSTITUTED ADENINYL ARABINOSIDES AS ANTI-CANCER AGENTS | SOUTHERN RESEARCH INSTITUTE (US) | 1992-11-26 | — | — | WO | disclosed |
| EP-0473708-A4 | 2-HALO-9-(2-DEOXY-2-FLUORO-B-D-ARABINOFURANOSYL) ADENINE NUCLEOSIDE DERIVATIVES | — | 1992-04-22 | — | — | EP | disclosed |
| US-5034518-A | Anticarcinogenic agents | SOUTHERN RESEARCH INSTITUTE (US) | 1991-07-23 | — | — | US | disclosed |
| WO-1990014352-A1 | 2-HALO-9-(2-DEOXY-2-FLUORO-B-D-ARABINOFURANOSYL) ADENINE NUCLEOSIDE DERIVATIVES | SOUTHERN RESEARCH INSTITUTE (US) | 1990-11-29 | — | — | WO | disclosed |