SCHEMBL8744192

SCHEMBL8744192

CCC(=O)OC/C=C/COC(=O)CC

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAAA Q02083 1/20 0.44
ALDH1A1 P00352 7/20 0.40
CYP1A2 P05177 1/20 0.40
HPGD P15428 1/20 0.40
CYP2C19 P33261 1/20 0.40
BLM P54132 1/20 0.40
WRN Q14191 1/20 0.40
HIF1A Q16665 1/20 0.40
GAA P10253 2/20 0.38
TSHR P16473 2/20 0.38
MGAM O43451 1/20 0.38
SI P14410 1/20 0.38
MGAM2 Q2M2H8 1/20 0.38
SOAT1 P35610 1/20 0.38
TRPA1 O75762 1/20 0.35
TDP1 Q9NUW8 2/20 0.33
FFAR3 O14843 1/20 0.33
LMNA P02545 1/20 0.33
HSD17B10 Q99714 1/20 0.33
HTT P42858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11292223 1.00 NAAA (0.44) NAAAALDH1A1CYP1A2HPGDCYP2C19
SCHEMBL8744195 1.00 NAAA (0.44) NAAAALDH1A1CYP1A2HPGDCYP2C19
SCHEMBL8961878 0.93 PTGS1 (0.40) NAAAALDH1A1CYP1A2HPGDCYP2C19
SCHEMBL30902248 0.91 ALDH1A1 (0.44) NAAAALDH1A1CYP1A2HPGDCYP2C19
SCHEMBL30902264 0.91 ALDH1A1 (0.44) NAAAALDH1A1CYP1A2HPGDCYP2C19
SCHEMBL2039597 0.89 NAAA (0.42) NAAAALDH1A1CYP1A2HPGDCYP2C19
SCHEMBL873462 0.89 NAAA (0.42) NAAAALDH1A1CYP1A2HPGDCYP2C19
SCHEMBL21467458 0.89 NAAA (0.38) NAAAALDH1A1CYP1A2HPGDCYP2C19
SCHEMBL873463 0.89 NAAA (0.42) NAAAALDH1A1CYP1A2HPGDCYP2C19
SCHEMBL1695314 0.87

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4544767-A HYDROGENATION CATALYST PHILLIPS PETROLEUM COMPANY (US) 1985-10-01 US claimed
US-4182901-A AND SUITABLE CARBOXYLIC ACID PHILLIPS PETROLEUM COMPANY (US) 1980-01-08 US claimed
US-4095030-A CARBOXYLIC ACID SALTS, DILUENTS PHILLIPS PETROLEUM COMPANY (US) 1978-06-13 US claimed
EP-0612720-B1 Process for producing 1,4-dicyano-2-butene SUMITOMO CHEMICAL CO (JP) 1997-01-08 EP disclosed
US-5463103-A Reacting butene derivative with hydrogen cyanide in presence of catalyst prepared from cuprous halide, lower alkylamine hydrohalide and Lewis acid or basic acetate, carbonate or bicarbonate SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-10-31 US disclosed
EP-0612720-A1 Process for producing 1,4-dicyano-2-butene SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-08-31 EP disclosed
US-4806679-A GAS OR LIQUID PHASE CATALYSIS WITH ZEOLITE; INTERMEDIATES BASF AKTIENGESELLSCHAFT (DE) 1989-02-21 US disclosed
EP-0132737-B1 PROCESS FOR THE ISOMERIZATION OF DIACYLOXYBUTENES BASF Aktiengesellschaft (DE) 1988-01-07 EP disclosed
US-4544767-A HYDROGENATION CATALYST PHILLIPS PETROLEUM COMPANY (US) 1985-10-01 US disclosed
EP-0132737-A2 Process for the isomerization of diacyloxybutenes BASF Aktiengesellschaft (DE) 1985-02-13 EP disclosed
US-4238356-A REACTION PRODUCT OF A CARBOXYLIC ACID, SELENIUM DIOXIDE, A HYDROXIDE OR ACID SALT, AND AN ACID ANHYDRIDE PHILLIPS PETROLEUM COMPANY (US) 1980-12-09 US disclosed
US-4182901-A AND SUITABLE CARBOXYLIC ACID PHILLIPS PETROLEUM COMPANY (US) 1980-01-08 US disclosed
US-4124619-A Preparation of esters of hydroxy tiglic aldehyde HOFFMANN-LA ROCHE INC. (US) 1978-11-07 US disclosed
US-4095030-A CARBOXYLIC ACID SALTS, DILUENTS PHILLIPS PETROLEUM COMPANY (US) 1978-06-13 US disclosed