Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.59 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.59 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.59 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.59 |
| ▸ | RARB | P10826 | 6/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RARA | P10276 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.44 |
| ▸ | BID | P55957 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6260223 | 0.83 | PTGER4 (0.67) | PTGER1PTGER4PTGER3PTGER2RARB | |
| SCHEMBL1982703 | 0.82 | HDAC8 (0.67) | PTGER1PTGER4PTGER3PTGER2RARB | |
| SCHEMBL2151219 | 0.82 | SIGMAR1 (0.62) | SIGMAR1 | |
| SCHEMBL8319817 | 0.82 | PTGER1 (0.61) | PTGER1PTGER4PTGER3PTGER2RARB | |
| SCHEMBL6825536 | 0.81 | TSHR (0.67) | TSHRALDH1A1MAPT | |
| SCHEMBL6256743 | 0.81 | PTGER1 (0.63) | PTGER1PTGER4PTGER3PTGER2RARB | |
| SCHEMBL6263046 | 0.81 | PTGER1 (0.59) | PTGER1PTGER4PTGER3PTGER2RARB | |
| SCHEMBL133470 | 0.80 | RARB (0.68) | PTGER1PTGER4PTGER3PTGER2RARB | |
| SCHEMBL6261303 | 0.80 | LMNA (0.53) | PTGER1PTGER4PTGER3PTGER2TSHR | |
| SCHEMBL19143887 | 0.79 | RARB (0.58) | PTGER1PTGER4PTGER3PTGER2RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752421-A1 | Ortho-substituted aromatic compounds, containing three (het)aryl moieties, their preparation and their use as prostaglandin E2-(PGE2)-antagonists | ZENECA LIMITED (GB) | 1997-01-08 | — | — | EP | disclosed |