SCHEMBL874443

SCHEMBL874443

ON=C(c1ccccc1)c1ccc(Cl)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GFER P55789 2/20 0.58
KMT2A Q03164 2/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
HPGD P15428 3/20 0.57
ALDH1A1 P00352 2/20 0.57
CES2 O00748 1/20 0.56
CES1 P23141 1/20 0.56
TSHR P16473 4/20 0.53
MAPT P10636 3/20 0.53
ALOX15 P16050 2/20 0.53
LMNA P02545 1/20 0.53
HTT P42858 1/20 0.53
POLB P06746 2/20 0.47
XBP1 P17861 1/20 0.47
NPSR1 Q6W5P4 2/20 0.46
MEN1 O00255 1/20 0.46
ESR1 P03372 1/20 0.44
ESR2 Q92731 1/20 0.44
GRIN2B Q13224 1/20 0.43
PPARG P37231 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11525026 0.91 LMNA (0.50) GFERKMT2ASMN1; SMN2HPGDALDH1A1
SCHEMBL28341134 0.88 HPGD (0.68) GFERKMT2ASMN1; SMN2HPGDALDH1A1
SCHEMBL27961040 0.85 HPGD (0.64) GFERKMT2ASMN1; SMN2HPGDALDH1A1
SCHEMBL273196 0.85 HPGD (0.64) GFERKMT2ASMN1; SMN2HPGDALDH1A1
Water SCHEMBL9518556 0.83 HPGD (0.61) GFERKMT2ASMN1; SMN2HPGDALDH1A1
SCHEMBL29509920 0.81 GFER (0.57) GFERKMT2ASMN1; SMN2HPGDALDH1A1
SCHEMBL10889415 0.80 CES2 (0.54) GFERKMT2ASMN1; SMN2HPGDCES2
SCHEMBL4036746 0.79 NPFFR1 (0.65) GFERKMT2ASMN1; SMN2HPGDALDH1A1
SCHEMBL4036744 0.79 NPFFR1 (0.65) GFERKMT2ASMN1; SMN2HPGDALDH1A1
SCHEMBL8632122 0.79 ESR1 (0.59) GFERKMT2AHPGDALDH1A1CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114835660-A Preparation method of oxime ether 浙江理工大学 2022-08-02 CN claimed
CN-110606855-B Polysubstituted benzothienoisoquinoline, derivative and synthesis method thereof 湘潭大学 2022-03-18 CN claimed
US-12492225-B2 Melanocyte-regulating peptides IDP DISCOVERY PHARMA, S.L. (ES) 2025-12-09 US disclosed
EP-4532513-A1 CYCLIC PEPTIDES WITH ANTIBACTERIAL ACTIVITY AGAINST MULTIDRUG RESISTANT (MDR) PATHOGENS Fundación Privada Instituto De Salud Global Barcelona (ES) 2025-04-09 EP disclosed
CN-119451974-A Cyclic peptides having antibacterial activity against Multiple Drug Resistant (MDR) pathogens 巴塞罗那全球健康研究所私人基金会 2025-02-14 CN disclosed
US-20240294573-A1 CONSTRAINED PEPTIDES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-09-05 US disclosed
US-20240083943-A1 VEGF-REGULATING PEPTIDES IDP DISCOVERY PHARMA, S.L. (ES) 2024-03-14 US disclosed
WO-2023227771-A1 CYCLIC PEPTIDES WITH ANTIBACTERIAL ACTIVITY AGAINST MULTIDRUG RESISTANT (MDR) PATHOGENS Fundación Privada Instituto De Salud Global Barcelona (ES) 2023-11-30 WO disclosed
EP-4271480-A1 VEGF-REGULATING PEPTIDES IDP Discovery Pharma, S.L. (ES) 2023-11-08 EP disclosed
CN-116964074-A Peptides that modulate VEGF IDP研发制药有限公司 2023-10-27 CN disclosed
CN-111263768-B anticancer peptides IDP研发制药有限公司 2023-10-13 CN disclosed
WO-2010011313-A2 LIGATION OF STAPLED POLYPEPTIDES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2010-01-28 WO disclosed
EP-2142562-A2 STITCHED POLYPEPTIDES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2010-01-13 EP disclosed
WO-2008127480-A2 PACKED BED MICROREACTORS CORNELL RESEARCH FOUNDATION, INC. (US) 2008-10-23 WO disclosed
WO-2008121767-A2 STITCHED POLYPEPTIDES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2008-10-09 WO disclosed
WO-2008028057-A2 SHIKIMIC ACID-DERIVED COMPOUNDS FOR INHIBITION AND DETECTION OF AURORA A-ASSOCIATED TUMORS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2008-03-06 WO disclosed
EP-0326516-B1 Method of making patterns CIBA GEIGY AG (CH) 1995-03-15 EP disclosed
US-5237059-A Compounds capable of generating an acid by light irradiation FUJI PHOTO FILM CO., LTD. (JP) 1993-08-17 US disclosed
US-4861438-A Method of making patterns CIBA-GEIGY CORPORATION (US) 1989-08-29 US disclosed
EP-0326516-A2 Method of making patterns CIBA-GEIGY AG (CH) 1989-08-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12492225-B2 Melanocyte-regulating peptides MC1R, MITF, MCHR1 GFER 4557/4885KMT2A 995/4885SMN1; SMN2 4367/4885
US-20240294573-A1 CONSTRAINED PEPTIDES IAPP, NGLY1, VIP GFER 4497/4885KMT2A 4628/4885SMN1; SMN2 1685/4885
US-20240083943-A1 VEGF-REGULATING PEPTIDES VEGFA, FLT4, FLT1 GFER 3286/4885KMT2A 3448/4885SMN1; SMN2 2505/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.