Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744746 | 1.00 | MAPK1 (0.40) | MAPK1PSMB5KMT2AMEN1FNTA | |
| SCHEMBL8744841 | 0.87 | MEN1 (0.51) | MAPK1KMT2AMEN1FNTAFNTB | |
| SCHEMBL8744835 | 0.87 | MEN1 (0.51) | MAPK1KMT2AMEN1FNTAFNTB | |
| SCHEMBL9595916 | 0.84 | USP2 (0.39) | PSMB5KMT2ALMNAUSP2POLB | |
| SCHEMBL8744728 | 0.84 | USP2 (0.39) | PSMB5KMT2ALMNAUSP2POLB | |
| SCHEMBL8744827 | 0.82 | MAPK1 (0.56) | MAPK1KMT2AMEN1LMNAPOLB | |
| SCHEMBL8744819 | 0.82 | MAPK1 (0.56) | MAPK1KMT2AMEN1LMNAPOLB | |
| SCHEMBL8744709 | 0.82 | ACE (0.55) | — | |
| SCHEMBL8744713 | 0.82 | ACE (0.55) | — | |
| SCHEMBL8744760 | 0.80 | POLB (0.47) | MAPK1PSMB5LMNAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |