Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PYGL | P06737 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GRN | P28799 | 2/20 | 0.48 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744827 | 1.00 | MAPK1 (0.56) | MAPK1ALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL6992737 | 0.88 | ALDH1A1 (0.49) | MAPK1ALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL6992741 | 0.88 | ALDH1A1 (0.49) | MAPK1ALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL6995117 | 0.87 | ALDH1A1 (0.50) | MAPK1ALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL6995119 | 0.87 | ALDH1A1 (0.50) | MAPK1ALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL8744806 | 0.84 | TAS1R3 (0.50) | MAPK1ALDH1A1KMT2APOLBLMNA | |
| SCHEMBL9593287 | 0.84 | TAS1R3 (0.50) | MAPK1ALDH1A1KMT2APOLBLMNA | |
| SCHEMBL8744760 | 0.83 | POLB (0.47) | MAPK1ALDH1A1POLBLMNAKDM4E | |
| SCHEMBL8744756 | 0.83 | POLB (0.47) | MAPK1ALDH1A1POLBLMNAKDM4E | |
| SCHEMBL8744755 | 0.82 | MAPK1 (0.40) | MAPK1ALDH1A1KMT2APOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |